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Atomfair 2-Fluoro-6-(trifluoromethyl)benzene-1-sulfonyl chloride C7H3ClF4O2S CAS 405264-04-2

2-Fluoro-6-(trifluoromethyl)benzene-1-sulfonyl chloride (CAS No. 405264-04-2) is a highly specialized sulfonyl chloride derivative with the molecular formula C7H3ClF4O2S . This compound is characterized by its reactive sulfonyl chloride group and electron-withdrawing trifluoromethyl and fluoro substituents, making it a valuable intermediate in organic synthesis and pharmaceutical research. It is supplied as a high-purity reagent (>98%) with strict quality control to ensure consistency in sensitive applications. Suitable for use in nucleophilic substitution reactions, coupling reactions, and as a precursor for sulfonamide synthesis. Store under inert conditions to prevent hydrolysis and degradation.

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Description

2-Fluoro-6-(trifluoromethyl)benzene-1-sulfonyl chloride (CAS No. 405264-04-2) is a highly specialized sulfonyl chloride derivative with the molecular formula C7H3ClF4O2S. This compound is characterized by its reactive sulfonyl chloride group and electron-withdrawing trifluoromethyl and fluoro substituents, making it a valuable intermediate in organic synthesis and pharmaceutical research. It is supplied as a high-purity reagent (>98%) with strict quality control to ensure consistency in sensitive applications. Suitable for use in nucleophilic substitution reactions, coupling reactions, and as a precursor for sulfonamide synthesis. Store under inert conditions to prevent hydrolysis and degradation.

Properties

  • CAS Number: 405264-04-2
  • Complexity: 321
  • IUPAC Name: 2-fluoro-6-(trifluoromethyl)benzenesulfonyl chloride
  • InChI: InChI=1S/C7H3ClF4O2S/c8-15(13,14)6-4(7(10,11)12)2-1-3-5(6)9/h1-3H
  • InChI Key: VVCAQQGQZZLRJK-UHFFFAOYSA-N
  • Exact Mass: 261.9478409
  • Molecular Formula: C7H3ClF4O2S
  • Molecular Weight: 262.61
  • SMILES: C1=CC(=C(C(=C1)F)S(=O)(=O)Cl)C(F)(F)F
  • Topological: 42.5
  • Monoisotopic Mass: 261.9478409
  • Synonyms: 405264-04-2, 2-fluoro-6-(trifluoroMethyl)benzene-1-sulfonyl chloride, 989-402-3, 2-fluoro-6-trifluoromethylphenylsulfonyl chloride, 2-FLUORO-6-(TRIFLUOROMETHYL)BENZENESULFONYL CHLORIDE, 2-fluoro-6-trifluoromethylbenzenesulfonyl chloride, SCHEMBL1501184, MFCD12032173, AKOS024118569, SY291272, DB-217358, D87787, EN300-9491833

Application

2-Fluoro-6-(trifluoromethyl)benzene-1-sulfonyl chloride is widely used as a key building block in medicinal chemistry for the synthesis of sulfonamide-based drug candidates. Its electron-deficient aromatic ring enhances reactivity in cross-coupling reactions, facilitating the development of fluorinated bioactive molecules. Researchers also employ it in materials science to modify polymer backbones or create sulfonated coatings with tailored properties. The compound’s stability under anhydrous conditions makes it ideal for controlled functionalization in multi-step syntheses.

Safety and Hazards

GHS Hazard Statements

  • H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
  • H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P260, P261, P264, P270, P271, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P319, P321, P330, P363, P403+P233, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 4 (100%)
  • Skin Corr. 1B (100%)
  • STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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