Description

Description

2-Fluoro-6-nitrobenzaldehyde (CAS No. 1644-82-2) is a high-purity aromatic aldehyde compound with the molecular formula C₇H₄FNO₃. This fluorinated nitrobenzaldehyde derivative is a versatile building block in organic synthesis, particularly in pharmaceutical and agrochemical research. The compound features a reactive aldehyde group ortho to both a fluorine atom and a nitro group, enabling selective functionalization for complex molecule construction. Available in ??98% purity by HPLC, this product is supplied as a crystalline solid with rigorous QC testing to ensure batch-to-batch consistency. Ideal for nucleophilic addition reactions, condensation reactions, and as a precursor for heterocyclic compounds. Store in cool, dry conditions away from light and oxidizing agents.

Key Specifications:
– CAS: 1644-82-2
– Molecular Weight: 169.11 g/mol
– Melting Point: 45-48??C
– Appearance: Yellow crystalline powder
– Hazard Codes: Xi (Irritant)

Application

2-Fluoro-6-nitrobenzaldehyde serves as a key intermediate in the synthesis of fluorinated pharmaceutical compounds, particularly in the development of kinase inhibitors and antimicrobial agents. The electron-withdrawing nitro and fluorine groups make this aldehyde particularly reactive in palladium-catalyzed cross-coupling reactions. Researchers utilize this compound as a precursor for synthesizing fluorinated quinoline and benzimidazole derivatives with potential biological activity. Its unique substitution pattern enables selective functionalization at either the aldehyde or nitro group for structure-activity relationship studies.

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