Description

2-Fluoro-6-methylaniline (CAS No. 443-89-0) is a high-purity organic compound with the molecular formula C₇H₈FN. This versatile aromatic amine features a fluorine substituent adjacent to an amino group on a methyl-substituted benzene ring, making it a valuable intermediate in pharmaceutical synthesis, agrochemical production, and advanced material research. Our product is rigorously tested to ensure ≥97% purity, meeting the stringent requirements of research laboratories and industrial applications. Supplied in sealed, light-resistant containers under inert atmosphere to maintain stability, this compound is ideal for nucleophilic substitution reactions, cross-coupling protocols, and as a building block for fluorinated heterocycles. Available in quantities from grams to kilograms with customizable packaging options.

Key Specifications:
• CAS: 443-89-0
• Molecular Weight: 125.15 g/mol
• Appearance: Clear pale yellow to amber liquid
• Purity: ≥97% (GC)
• Density: ~1.1 g/cm³
• Storage: 2-8°C under nitrogen
• Hazard Codes: T (Toxic)

Properties

• CAS Number: 443-89-0
• Complexity: 94.9
• IUPAC Name: 2-fluoro-6-methyl-aniline
• InChI: InChI=1S/C7H8FN/c1-5-3-2-4-6(8)7(5)9/h2-4H,9H2,1H3
• InChI Key: CMVJYZNBMRJICR-UHFFFAOYSA-N
• Exact Mass: 125.064077422
• Molecular Formula: C7H8FN
• Molecular Weight: 125.14
• SMILES: CC1=C(C(=CC=C1)F)N
• Topological: 26
• Monoisotopic Mass: 125.064077422
• Synonyms: 2-Fluoro-6-methylaniline, 443-89-0, DTXSID30556742, DTXCID00507524, 626-933-9, 2-Amino-3-Fluorotoluene, MFCD06658252, 2-fluoro-6-methyl-phenylamine, 6-Fluoro-o-toluidine, 3-fluoro-2-aminotoluene, BENZENAMINE, 2-FLUORO-6-METHYL-, 2-fluoro-6-methylbenzenamine, 6-fluoro-2-methylphenylamine, SCHEMBL1639725, SCHEMBL6653202, SCHEMBL7746054, (2-fluoro-6-methylphenyl)amine, 2-Fluoro-6-methylaniline, 97%, CMVJYZNBMRJICR-UHFFFAOYSA-N, BCP21252, BBL101151, CL8817, GEO-02691, SBB069823, STL554947, AKOS005257304, AC-1833, CS-W011172, MB03934, PS-9193, SY013815, SY294453, DB-005244, A7045, F0817, EN300-98386

2-Fluoro-6-methylaniline serves as a critical precursor in the synthesis of fluorinated pharmaceutical compounds, particularly in developing kinase inhibitors and CNS-active agents. Its electron-deficient aromatic ring facilitates palladium-catalyzed cross-coupling reactions for constructing complex biaryl systems. The compound finds specialized use in agrochemical research for creating novel pesticidal molecules with enhanced metabolic stability. Researchers also employ it as a derivatization agent in analytical chemistry for detecting carbonyl compounds via Schiff base formation.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (97.7%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H335 (97.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (97.7%)
• STOT SE 3 (97.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.