Description

2-Fluoro-6-hydroxybenzonitrile (CAS No. 140675-43-0) is a high-purity fluorinated aromatic compound with the molecular formula C₇H₄FNO. This specialty chemical is widely utilized in pharmaceutical and agrochemical research due to its unique structural features, combining a fluorine substituent with a hydroxyl and nitrile group on a benzene ring. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied as a white to off-white crystalline powder. Ideal for use as a building block in organic synthesis, this compound offers excellent reactivity for nucleophilic substitution, coupling reactions, and as a precursor for heterocyclic compounds. Each batch is accompanied by comprehensive analytical data including ¹H NMR, ¹³C NMR, HPLC chromatograms, and mass spectrometry results. Available in quantities from grams to kilograms with custom packaging options.

Properties

• CAS Number: 140675-43-0
• Complexity: 162
• IUPAC Name: 2-fluoro-6-hydroxy-benzonitrile
• InChI: InChI=1S/C7H4FNO/c8-6-2-1-3-7(10)5(6)4-9/h1-3,10H
• InChI Key: YEBHNFDMNFHZFF-UHFFFAOYSA-N
• Exact Mass: 137.027691913
• Molecular Formula: C7H4FNO
• Molecular Weight: 137.11
• SMILES: C1=CC(=C(C(=C1)F)C#N)O
• Topological: 44
• Monoisotopic Mass: 137.027691913
• Synonyms: 2-fluoro-6-hydroxybenzonitrile, 140675-43-0, 2-Cyano-3-Fluorophenol, DTXSID00382515, DTXCID80333540, 642-487-8, Benzonitrile, 2-fluoro-6-hydroxy-, MFCD03428592, 6-fluorosalicylonitrile, 6-Fluoro-2-hydroxybenzonitrile, 2-FLUORO-6-HYDROXYBENZONITRLE, SCHEMBL30978, 2-hydroxy-6-fluorobenzonitrile, SCHEMBL3154084, 2-fluoro-6-hydroxybenzenecarbonitrile, CL8166, SBB055260, AKOS005254993, AC-4070, CCG-302513, CS-W018318, EG-0028, FF64144, SY021121, DB-021106, F0985, EN300-43317, Z425420618

Application

2-Fluoro-6-hydroxybenzonitrile serves as a key intermediate in the synthesis of fluorinated pharmaceuticals and bioactive molecules. Researchers utilize this compound in the development of kinase inhibitors and other therapeutic agents where fluorine substitution enhances metabolic stability. The hydroxyl and nitrile functional groups make it particularly valuable for constructing complex heterocyclic scaffolds through condensation and cyclization reactions. In material science, it finds application as a precursor for specialty polymers with enhanced thermal stability.

Safety and Hazards

GHS Hazard Statements

• H301+H311+H331 (11.1%): Toxic if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
• H301 (22.2%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302 (77.8%): Harmful if swallowed [Warning Acute toxicity, oral]
• H311 (22.2%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H312 (77.8%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H331 (22.2%): Toxic if inhaled [Danger Acute toxicity, inhalation]
• H332 (77.8%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (88.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (22.2%)
• Acute Tox. 4 (77.8%)
• Acute Tox. 3 (22.2%)
• Acute Tox. 4 (77.8%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 3 (22.2%)
• Acute Tox. 4 (77.8%)
• STOT SE 3 (88.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.