Description

2-Fluoro-5-(trifluoromethyl)benzyl alcohol (CAS No. 207974-09-2) is a high-purity fluorinated benzyl alcohol derivative with the molecular formula C₈H₆F₄O. This compound, also known by its IUPAC name [2-fluoro-5-(trifluoromethyl)phenyl]methanol, is a versatile building block in organic synthesis and pharmaceutical research. Its unique structure, featuring both fluorine and trifluoromethyl groups, enhances its reactivity and makes it valuable for designing novel bioactive molecules. The product is supplied as a clear, colorless to pale yellow liquid with ≥95% purity (GC), ensuring optimal performance in demanding applications. Proper storage under inert conditions at 2-8°C is recommended to maintain stability.

Properties

• CAS Number: 207974-09-2
• Complexity: 168
• IUPAC Name: [2-fluoro-5-(trifluoromethyl)phenyl]methanol
• InChI: InChI=1S/C8H6F4O/c9-7-2-1-6(8(10,11)12)3-5(7)4-13/h1-3,13H,4H2
• InChI Key: LFWIVOZRZSAKAL-UHFFFAOYSA-N
• Exact Mass: 194.03547746
• Molecular Formula: C8H6F4O
• Molecular Weight: 194.13
• SMILES: C1=CC(=C(C=C1C(F)(F)F)CO)F
• Topological: 20.2
• Monoisotopic Mass: 194.03547746
• Synonyms: 2-Fluoro-5-(trifluoromethyl)benzyl alcohol, 207974-09-2, DTXSID10343394, DTXCID70294474, lfwivozrzsakal-uhfffaoysa-n, (2-fluoro-5-(trifluoromethyl)phenyl)methanol, [2-Fluoro-5-(trifluoromethyl)phenyl]methanol, benzenemethanol, 2-fluoro-5-(trifluoromethyl)-, MFCD00061167, 2-fluoro-5-trifluoromethylbenzyl alcohol, [2-fluoro-5-(trifluoromethyl)phenyl]methan-1-ol, SCHEMBL1167122, SCHEMBL27634850, CK2480, SBB091687, AKOS005255569, CS-W015748, PS-8306, SY061729, DB-045379, ST50407088, [2-Fluoro-5-(trifluoromethyl)phenyl]methanol #, EN300-1933569, [2-Fluoro-5-(trifluoromethyl)phenyl]methanol, AldrichCPR

Application

2-Fluoro-5-(trifluoromethyl)benzyl alcohol serves as a key intermediate in the synthesis of fluorinated pharmaceuticals, agrochemicals, and liquid crystals. Its electron-withdrawing substituents make it particularly useful in nucleophilic aromatic substitution reactions and cross-coupling chemistry. Researchers employ this compound to develop protease inhibitors and other therapeutic agents targeting CNS disorders. It also finds application in material science for creating advanced polymers with enhanced thermal and chemical resistance.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (100%)

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