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Atomfair 2-Fluoro-5-(trifluoromethyl)aniline C7H5F4N CAS 535-52-4
2-Fluoro-5-(trifluoromethyl)aniline (CAS No. 535-52-4) is a high-purity fluorinated aromatic amine with the molecular formula C7H5F4N . This specialized compound is widely utilized in pharmaceutical, agrochemical, and materials science research due to its unique trifluoromethyl and fluoro substituents, which enhance reactivity and stability. It is supplied as a clear to pale-yellow liquid with a purity of ≥98% (GC), ensuring consistency for synthetic applications. Ideal for nucleophilic substitution reactions, cross-coupling, and as a building block for advanced intermediates. Proper storage under inert atmosphere at 2-8°C is recommended to maintain integrity.
Description
2-Fluoro-5-(trifluoromethyl)aniline (CAS No. 535-52-4) is a high-purity fluorinated aromatic amine with the molecular formula C7H5F4N. This specialized compound is widely utilized in pharmaceutical, agrochemical, and materials science research due to its unique trifluoromethyl and fluoro substituents, which enhance reactivity and stability. It is supplied as a clear to pale-yellow liquid with a purity of ≥98% (GC), ensuring consistency for synthetic applications. Ideal for nucleophilic substitution reactions, cross-coupling, and as a building block for advanced intermediates. Proper storage under inert atmosphere at 2-8°C is recommended to maintain integrity.
Properties
- CAS Number: 535-52-4
- Complexity: 156
- IUPAC Name: 2-fluoro-5-(trifluoromethyl)aniline
- InChI: InChI=1S/C7H5F4N/c8-5-2-1-4(3-6(5)12)7(9,10)11/h1-3H,12H2
- InChI Key: DRKWGMXFFCPZLW-UHFFFAOYSA-N
- Exact Mass: 179.03581181
- Molecular Formula: C7H5F4N
- Molecular Weight: 179.11
- SMILES: C1=CC(=C(C=C1C(F)(F)F)N)F
- Topological: 26
- Monoisotopic Mass: 179.03581181
- Synonyms: 2-Fluoro-5-(trifluoromethyl)aniline, 626-503-0, 535-52-4, 3-Amino-4-fluorobenzotrifluoride, alpha,alpha,alpha,6-Tetrafluoro-m-toluidine, 2-Fluoro-5-trifluoromethylaniline, MFCD00007653, 2-fluoro-5-(trifluoromethyl)benzenamine, 2-fluoro-5-(trifluoromethyl)phenylamine, .alpha.,.alpha.,.alpha.,6-Tetrafluoro-m-toluidine, Benzenamine, 2-fluoro-5-(trifluoromethyl)-, 3-Amino-4-fluorobenzotrifluoride; NSC 10327; alpha,alpha,alpha,6-Tetrafluoro-m-toluidine, NSC10327, SCHEMBL309479, 2-fluoro-5-trifluoromethylanilin, a,a,a,6-Tetrafluoro-m-toluidine, DTXSID80201710, 2-fluoro-5-trifloromethyl aniline, 2-fluoro-5-trifluoromethyl aniline, ALBB-001513, BBL016355, NSC 10327, NSC-10327, SBB028384, STK398231, 2-fluoro-5-(trifluoromethyl) aniline, AKOS003284066, 2-Fluoro-5-(trifluoromethyl)aniline #, CS-W017290, PS-8550, AC-26227, 2-Fluoro-5-(trifluoromethyl)aniline, 97%, DB-021090, A7788, ST50405104, EN300-67467, Z275189668, 3-Amino-4-fluorobenzotrifluoride;alpha,alpha,alpha,6-Tetrafluoro-m-toluidine
Application
2-Fluoro-5-(trifluoromethyl)aniline serves as a key intermediate in the synthesis of fluorinated pharmaceuticals, including kinase inhibitors and antiviral agents. Its electron-withdrawing groups make it valuable in agrochemical development for crop protection compounds. Researchers also employ it in materials science to engineer fluorinated polymers with enhanced thermal and chemical resistance.
Safety and Hazards
GHS Hazard Statements
- H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
- H312 (91.3%): Harmful in contact with skin [Warning Acute toxicity, dermal]
- H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
- H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
- H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]
- H335 (87%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Precautionary Statements
- P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501
Hazard Classes and Categories
- Acute Tox. 4 (100%)
- Acute Tox. 4 (91.3%)
- Skin Irrit. 2 (100%)
- Eye Irrit. 2 (100%)
- Acute Tox. 4 (100%)
- STOT SE 3 (87%)
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