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Atomfair 2-Fluoro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine C10H14BFN2O2 CAS 1352796-65-6

2-Fluoro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine (CAS: 1352796-65-6) is a high-purity boronic ester derivative designed for advanced synthetic applications in pharmaceutical and materials research. With the molecular formula C10H14BFN2O2, this compound features a pyrimidine ring functionalized with a fluorine substituent and a pinacol boronate ester group, making it a versatile building block for Suzuki-Miyaura cross-coupling reactions. Its IUPAC name, 2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine , reflects its precise structural configuration. This reagent is supplied as a stable, crystalline solid with rigorous QC validation (≥95% purity by HPLC) to ensure reproducibility in organoboron chemistry, medicinal chemistry, and agrochemical development. Ideal for constructing fluorinated heterocycles, it is packaged under inert conditions…

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Description

2-Fluoro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine (CAS: 1352796-65-6) is a high-purity boronic ester derivative designed for advanced synthetic applications in pharmaceutical and materials research. With the molecular formula C10H14BFN2O2, this compound features a pyrimidine ring functionalized with a fluorine substituent and a pinacol boronate ester group, making it a versatile building block for Suzuki-Miyaura cross-coupling reactions. Its IUPAC name, 2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine, reflects its precise structural configuration. This reagent is supplied as a stable, crystalline solid with rigorous QC validation (≥95% purity by HPLC) to ensure reproducibility in organoboron chemistry, medicinal chemistry, and agrochemical development. Ideal for constructing fluorinated heterocycles, it is packaged under inert conditions to prevent hydrolysis and degradation.

Properties

  • CAS Number: 1352796-65-6
  • Complexity: 252
  • IUPAC Name: 2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
  • InChI: InChI=1S/C10H14BFN2O2/c1-9(2)10(3,4)16-11(15-9)7-5-13-8(12)14-6-7/h5-6H,1-4H3
  • InChI Key: XFNGULIUEUPWIG-UHFFFAOYSA-N
  • Exact Mass: 224.1132360
  • Molecular Formula: C10H14BFN2O2
  • Molecular Weight: 224.04
  • SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CN=C(N=C2)F
  • Topological: 44.2
  • Monoisotopic Mass: 224.1132360
  • Synonyms: 1352796-65-6, 2-fluoro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine, 962-261-5, 2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine, 2-FLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER, 2-FLUOROPYRIMIDIN-5-YLBORONIC ACID PINACOL ESTER, MFCD13182191, C10H14BFN2O2, SCHEMBL20137083, AT16047, MB13052, BS-26581, SY068156, DB-134807, CS-0145801, EN300-7002030

Application

This compound is widely used as a key intermediate in the synthesis of fluorinated pyrimidine derivatives via palladium-catalyzed cross-coupling reactions. It enables the introduction of boronate-functionalized pyrimidine scaffolds into complex molecules for drug discovery, particularly in kinase inhibitor development. Researchers also employ it in materials science to modify electronic properties of conjugated systems. Its stability under anhydrous conditions makes it suitable for multi-step synthetic workflows.

Safety and Hazards

GHS Hazard Statements

  • H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 4 (100%)
  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2A (100%)
  • STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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