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Atomfair 2-Fluoro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine C10H14BFN2O2

Description 2-Fluoro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine (CAS: 1352796-65-6) is a high-purity boronic ester derivative designed for advanced synthetic applications in pharmaceutical and materials research. With the molecular formula C10H14BFN2O2, this compound features a pyrimidine ring functionalized with a fluorine substituent and a pinacol boronate ester group, making it a versatile building block for Suzuki-Miyaura cross-coupling reactions. Its IUPAC name, 2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine , reflects its precise structural configuration. This reagent is supplied as a stable, crystalline solid with rigorous QC validation (??95% purity by HPLC) to ensure reproducibility in organoboron chemistry, medicinal chemistry, and agrochemical development. Ideal for constructing fluorinated heterocycles, it is packaged under inert…

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Description

Description

2-Fluoro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine (CAS: 1352796-65-6) is a high-purity boronic ester derivative designed for advanced synthetic applications in pharmaceutical and materials research. With the molecular formula C10H14BFN2O2, this compound features a pyrimidine ring functionalized with a fluorine substituent and a pinacol boronate ester group, making it a versatile building block for Suzuki-Miyaura cross-coupling reactions. Its IUPAC name, 2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine, reflects its precise structural configuration. This reagent is supplied as a stable, crystalline solid with rigorous QC validation (??95% purity by HPLC) to ensure reproducibility in organoboron chemistry, medicinal chemistry, and agrochemical development. Ideal for constructing fluorinated heterocycles, it is packaged under inert conditions to prevent hydrolysis and degradation.

  • CAS No: 1352796-65-6
  • Molecular Formula: C10H14BFN2O2
  • Molecular Weight: 224.04
  • Exact Mass: 224.1132360
  • Monoisotopic Mass: 224.1132360
  • IUPAC Name: 2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
  • SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CN=C(N=C2)F
  • Synonyms: 1352796-65-6, 2-fluoro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine, 962-261-5, 2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine, 2-FLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER

Application

This compound is widely used as a key intermediate in the synthesis of fluorinated pyrimidine derivatives via palladium-catalyzed cross-coupling reactions. It enables the introduction of boronate-functionalized pyrimidine scaffolds into complex molecules for drug discovery, particularly in kinase inhibitor development. Researchers also employ it in materials science to modify electronic properties of conjugated systems. Its stability under anhydrous conditions makes it suitable for multi-step synthetic workflows.

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