Description

2-Fluoro-5-nitropyridine (CAS No. 456-24-6) is a high-purity heterocyclic compound with the molecular formula C₅H₃FN₂O₂, widely utilized in pharmaceutical and agrochemical research. This nitropyridine derivative features a fluorine atom at the 2-position and a nitro group at the 5-position, offering unique reactivity for nucleophilic substitution and cross-coupling reactions. Its crystalline solid form and stability under controlled conditions make it ideal for synthetic applications. Suitable for advanced organic synthesis, this compound is rigorously tested for purity (typically ≥97% by GC or HPLC) and is available in various packaging options to meet laboratory-scale or bulk requirements. Store in a cool, dry place away from light and moisture to ensure prolonged shelf life.

Properties

• CAS Number: 456-24-6
• Complexity: 136
• IUPAC Name: 2-fluoro-5-nitro-pyridine
• InChI: InChI=1S/C5H3FN2O2/c6-5-2-1-4(3-7-5)8(9)10/h1-3H
• InChI Key: XOZAJNLUAODXSP-UHFFFAOYSA-N
• Exact Mass: 142.01785550
• Molecular Formula: C5H3FN2O2
• Molecular Weight: 142.09
• SMILES: C1=CC(=NC=C1[N+](=O)[O-])F
• Topological: 58.7
• Monoisotopic Mass: 142.01785550
• Synonyms: 2-Fluoro-5-nitropyridine, 456-24-6, EINECS 207-260-6, DTXSID70196565, NSC 26280, DTXCID10119056, 207-260-6, 6-Fluoro-3-nitropyridine, 2-fluoro-5-nitro-pyridine, MFCD03095059, PYRIDINE, 2-FLUORO-5-NITRO-, 5-nitro-2-fluoropyridine, NSC26280, SCHEMBL1163154, BCP23147, CS-D0968, BBL100718, NSC-26280, STL554512, 2-Fluoro-5-nitropyridine, AldrichCPR, AKOS005063588, AKOS005145591, AB13439, AC-5942, AS-14966, SY010502, DB-031387, F0983, NS00043597, EN300-104104

Application

2-Fluoro-5-nitropyridine serves as a versatile building block in medicinal chemistry, particularly in the synthesis of fluorinated pyridine-based drug candidates. It is employed in the development of kinase inhibitors and antimicrobial agents due to its electron-withdrawing nitro and fluorine groups. Researchers also use it as a precursor for functionalized pyridines in material science and agrochemical applications.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (50%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.