Description

2-Fluoro-5-nitrobenzoic acid (CAS No. 7304-32-7) is a high-purity fluorinated nitrobenzoic acid derivative with the molecular formula C₇H₄FNO₄. This compound is a versatile building block in organic synthesis, pharmaceutical research, and material science applications. Its unique structure, featuring both a fluorine substituent and a nitro group on the aromatic ring, makes it an excellent intermediate for the development of active pharmaceutical ingredients (APIs), agrochemicals, and specialty chemicals. Available in >98% purity (HPLC), this product is rigorously tested for quality, ensuring optimal performance in demanding research environments. Suitable for use in nucleophilic substitution reactions, cross-coupling reactions, and as a precursor for heterocyclic compounds. Packaged under inert gas to ensure stability and supplied with comprehensive analytical data (MSDS, NMR, HPLC).

Properties

• CAS Number: 7304-32-7
• Complexity: 227
• IUPAC Name: 2-fluoro-5-nitro-benzoic acid
• InChI: InChI=1S/C7H4FNO4/c8-6-2-1-4(9(12)13)3-5(6)7(10)11/h1-3H,(H,10,11)
• InChI Key: ICXSHFWYCHJILC-UHFFFAOYSA-N
• Exact Mass: 185.01243577
• Molecular Formula: C7H4FNO4
• Molecular Weight: 185.11
• SMILES: C1=CC(=C(C=C1[N+](=O)[O-])C(=O)O)F
• Topological: 83.1
• Monoisotopic Mass: 185.01243577
• Synonyms: 2-Fluoro-5-nitrobenzoic acid, 7304-32-7, DTXSID90299880, DTXCID00251015, 627-772-7, inchi=1/c7h4fno4/c8-6-2-1-4(9(12)13)3-5(6)7(10)11/h1-3h,(h,10,11, 2-Fluoro-5-nitrobenzoicacid, MFCD00134238, NSC 133450;, 2-fluoro-5-nitro-benzoic acid, Benzoic acid, 2-fluoro-5-nitro-, 2-Fluoro-5-nitro-benzoicacid, NSC133450, SCHEMBL195145, 2-Fluoro-5-nitro benzoic acid, SCHEMBL1654660, BBL011905, SBB028509, STK802601, 2-Fluoro-5-nitrobenzoic acid, 98%, AKOS003620481, AC-3983, CS-W007433, FF23410, NSC 133450, NSC-133450, AS-14478, SY016914, DB-025342, A9457, F0391, ST50407284, EN300-27785, AN-652/42287618, F0001-1850, Z235361915

Application

2-Fluoro-5-nitrobenzoic acid is widely used as a key intermediate in pharmaceutical synthesis, particularly in the development of fluorinated drug candidates. It serves as a precursor for the preparation of bioactive molecules, including enzyme inhibitors and receptor modulators. Researchers also utilize this compound in material science for the synthesis of advanced polymers and liquid crystals. Its nitro group enables further functionalization via reduction or substitution reactions, expanding its utility in combinatorial chemistry.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (98%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (98%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.