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Atomfair 2-Fluoro-5-methoxybenzene-1-sulfonyl chloride C7H6ClFO3S

Description 2-Fluoro-5-methoxybenzene-1-sulfonyl chloride (CAS No. 1214334-01-6) is a high-purity sulfonyl chloride derivative designed for advanced synthetic applications in pharmaceutical and chemical research. With the molecular formula C7H6ClFO3S and a molecular weight of 224.63 g/mol, this compound features a reactive sulfonyl chloride group (?CSO2Cl) adjacent to a fluoro-methoxy-substituted benzene ring, making it a versatile intermediate for nucleophilic substitution and coupling reactions. Ideal for constructing sulfonamides, sulfonate esters, and other sulfur-containing scaffolds, this reagent is rigorously tested for consistency, stability, and low impurity profiles (??95% purity by HPLC). Packaged under inert gas to prevent hydrolysis, it is supplied in amber glass vials…

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Description

Description

2-Fluoro-5-methoxybenzene-1-sulfonyl chloride (CAS No. 1214334-01-6) is a high-purity sulfonyl chloride derivative designed for advanced synthetic applications in pharmaceutical and chemical research. With the molecular formula C7H6ClFO3S and a molecular weight of 224.63 g/mol, this compound features a reactive sulfonyl chloride group (?CSO2Cl) adjacent to a fluoro-methoxy-substituted benzene ring, making it a versatile intermediate for nucleophilic substitution and coupling reactions. Ideal for constructing sulfonamides, sulfonate esters, and other sulfur-containing scaffolds, this reagent is rigorously tested for consistency, stability, and low impurity profiles (??95% purity by HPLC). Packaged under inert gas to prevent hydrolysis, it is supplied in amber glass vials with secure closures to ensure long-term storage integrity. Suitable for use in medicinal chemistry, agrochemical development, and material science applications.

  • CAS No: 1214334-01-6
  • Molecular Formula: C7H6ClFO3S
  • Molecular Weight: 224.64
  • Exact Mass: 223.9710211
  • Monoisotopic Mass: 223.9710211
  • IUPAC Name: 2-fluoro-5-methoxybenzenesulfonyl chloride
  • SMILES: COC1=CC(=C(C=C1)F)S(=O)(=O)Cl
  • Synonyms: 2-Fluoro-5-methoxybenzene-1-sulfonyl chloride, 1214334-01-6, DTXSID90577478, DTXCID50528249, 855-107-2

Application

2-Fluoro-5-methoxybenzene-1-sulfonyl chloride is widely employed as a key building block in the synthesis of sulfonamide-based pharmaceuticals, including protease inhibitors and antibacterial agents. Its electron-withdrawing fluoro and methoxy groups enhance reactivity in palladium-catalyzed cross-coupling reactions, facilitating the creation of complex heterocycles. Researchers also utilize this compound to develop fluorescent probes and polymer modifiers due to its tunable aromatic system. Strict handling under anhydrous conditions is recommended to preserve its sulfonyl chloride functionality.

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