Description

2-Fluoro-5-methoxyaniline (CAS No. 62257-15-2) is a high-purity aromatic amine derivative with the molecular formula C₇H₈FNO. This compound features a fluorine substituent at the 2-position and a methoxy group at the 5-position of the aniline ring, offering unique reactivity for advanced synthetic applications. Ideal for pharmaceutical intermediates, agrochemical research, and material science, this reagent is rigorously tested to ensure ≥98% purity (HPLC/GC). Available in sealed amber vials or bulk quantities under inert gas to prevent degradation. Store in a cool, dry place away from light and oxidizing agents. Suitable for use in coupling reactions, heterocycle synthesis, and as a building block for fluorinated compounds.

Properties

• CAS Number: 62257-15-2
• Complexity: 110
• IUPAC Name: 2-fluoro-5-methoxy-aniline
• InChI: InChI=1S/C7H8FNO/c1-10-5-2-3-6(8)7(9)4-5/h2-4H,9H2,1H3
• InChI Key: RUTKJXMYXZFXPQ-UHFFFAOYSA-N
• Exact Mass: 141.058992041
• Molecular Formula: C7H8FNO
• Molecular Weight: 141.14
• SMILES: COC1=CC(=C(C=C1)F)N
• Topological: 35.3
• Monoisotopic Mass: 141.058992041
• Synonyms: 2-Fluoro-5-methoxyaniline, 62257-15-2, DTXSID60543842, DTXCID00494627, 694-924-7, 2-fluoro-5-methoxy-aniline, Benzenamine, 2-fluoro-5-methoxy- (9CI), MFCD11226283, 2-fluoro-5-methoxybenzenamine, BENZENAMINE, 2-FLUORO-5-METHOXY-, SCHEMBL1187335, RUTKJXMYXZFXPQ-UHFFFAOYSA-N, BCP25452, CL8982, AKOS006309619, AC-4495, CS-W009062, FF66275, BS-13341, SY043061, DB-012004, EN300-93472, Z1198319952, Benzenamine, 2-fluoro-5-methoxy- (9CI) 2-fluoro-5-methoxyaniline 3-Amino-4-fluoroanisole, 6-Fluoro-m-anisidine 2-Fluoro-5-Methoxy-p

Application

2-Fluoro-5-methoxyaniline serves as a versatile intermediate in the synthesis of fluorinated pharmaceuticals, particularly in the development of kinase inhibitors and antipsychotic agents. Its electron-rich aromatic system facilitates palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination). Researchers utilize this compound to introduce fluorine-methoxy motifs into liquid crystal materials for enhanced dielectric properties. In agrochemistry, it acts as a precursor for herbicides with improved metabolic stability.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 4 (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.