Description

2-Fluoro-5-formylpyridine (CAS No. 677728-92-6) is a high-purity fluorinated pyridine derivative with the molecular formula C₆H₄FNO. This compound, also known as 6-fluoropyridine-3-carbaldehyde, is a versatile building block in pharmaceutical and agrochemical research. Its unique structure, featuring both a fluorine substituent and an aldehyde functional group, makes it ideal for nucleophilic addition reactions, cross-coupling, and as a precursor for heterocyclic synthesis. Our product is rigorously tested for purity (typically ≥97% by GC/HPLC) and is supplied in stable, moisture-resistant packaging to ensure optimal shelf life. Suitable for use in medicinal chemistry, material science, and as a ligand in catalysis.

Properties

• CAS Number: 677728-92-6
• Complexity: 107
• IUPAC Name: 6-fluoropyridine-3-carbaldehyde
• InChI: InChI=1S/C6H4FNO/c7-6-2-1-5(4-9)3-8-6/h1-4H
• InChI Key: PZPNGWWKCSJKOS-UHFFFAOYSA-N
• Exact Mass: 125.027691913
• Molecular Formula: C6H4FNO
• Molecular Weight: 125.10
• SMILES: C1=CC(=NC=C1C=O)F
• Topological: 30
• Monoisotopic Mass: 125.027691913
• Synonyms: 2-FLUORO-5-FORMYLPYRIDINE, 692-035-9, 677728-92-6, 6-Fluoronicotinaldehyde, 2-Fluoropyridine-5-carbaldehyde, 2-Fluoropyridine-5-carboxaldehyde, 6-fluoropyridine-3-carbaldehyde, MFCD08064049, 6-fluoro-3-pyridinecarboxaldehyde, 2-FLUORO-5-PYRIDINECARBOXALDEHYDE, 3-PYRIDINECARBOXALDEHYDE, 6-FLUORO-, 2-fluoro-5-formyl pyridine, Nicotinamidase Inhibitor, 21, SCHEMBL114830, SCHEMBL1041994, BDBM92854, 6-fluoro-pyridine-3-carbaldehyde, DTXSID80585986, 6-fluoranylpyridine-3-carbaldehyde, 6-fluoro-3-pyridine carboxaldehyde, BBL103956, SBB052255, STL557766, AKOS006344489, AC-1873, CS-W004680, PB23560, PS-9205, FF137475, SY022307, DB-024991, EN300-112291, A835884

Application

2-Fluoro-5-formylpyridine is widely used as a key intermediate in the synthesis of fluorinated pharmaceuticals, particularly kinase inhibitors and antiviral agents. Its aldehyde group enables facile condensation reactions for constructing heterocyclic scaffolds, while the fluorine atom enhances metabolic stability in drug candidates. Researchers also employ it in metal-organic framework (MOF) synthesis and as a derivatization agent in analytical chemistry.

Safety and Hazards

GHS Hazard Statements

• H302 (75%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (75%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (75%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (75%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (75%)
• Acute Tox. 4 (75%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (75%)
• STOT SE 3 (75%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.