Description

2-Fluoro-4-(trifluoromethyl)benzyl alcohol (CAS No. 197239-49-9) is a high-purity fluorinated benzyl alcohol derivative with the molecular formula C₈H₆F₄O. This compound, also known by its IUPAC name [2-fluoro-4-(trifluoromethyl)phenyl]methanol, is a valuable building block in organic synthesis and pharmaceutical research. Its unique structure, featuring both fluorine and trifluoromethyl substituents, enhances its reactivity and makes it an ideal intermediate for the development of advanced materials, agrochemicals, and bioactive molecules.

Our product is rigorously tested to ensure ≥98% purity (GC) and is supplied in sealed containers under inert atmosphere to guarantee stability. Suitable for use in nucleophilic substitutions, cross-coupling reactions, and as a precursor for chiral auxiliaries. Available in quantities from milligrams to kilograms to meet both research and bulk-scale demands.

Key Features:
– High reactivity for functional group transformations
– Fluorine-rich scaffold for medicinal chemistry applications
– Compatible with Grignard reactions, esterifications, and oxidations
– Stored under nitrogen to prevent degradation

Properties

• CAS Number: 197239-49-9
• Complexity: 168
• IUPAC Name: [2-fluoro-4-(trifluoromethyl)phenyl]methanol
• InChI: InChI=1S/C8H6F4O/c9-7-3-6(8(10,11)12)2-1-5(7)4-13/h1-3,13H,4H2
• InChI Key: IOCYBFIAGBIYJU-UHFFFAOYSA-N
• Exact Mass: 194.03547746
• Molecular Formula: C8H6F4O
• Molecular Weight: 194.13
• SMILES: C1=CC(=C(C=C1C(F)(F)F)F)CO
• Topological: 20.2
• Monoisotopic Mass: 194.03547746
• Synonyms: 197239-49-9, 2-FLUORO-4-(TRIFLUOROMETHYL)BENZYL ALCOHOL, (2-Fluoro-4-(trifluoromethyl)phenyl)methanol, [2-fluoro-4-(trifluoromethyl)phenyl]methanol, Benzenemethanol, 2-fluoro-4-(trifluoromethyl)-, MFCD00070808, [2-fluoro-4-(trifluoromethyl)phenyl]methan-1-ol, SCHEMBL857195, SCHEMBL27634838, DTXSID90372142, SBB091685, AKOS006229557, AT22427, CS-W010667, JS-4097, SY061761, DB-044950, ST50407165, EN300-1934935

Application

2-Fluoro-4-(trifluoromethyl)benzyl alcohol serves as a versatile intermediate in pharmaceutical synthesis, particularly for introducing fluorine-containing motifs into drug candidates to enhance metabolic stability and bioavailability. It is employed in the preparation of liquid crystal materials due to its polar trifluoromethyl group. Researchers also utilize this compound to develop novel PET (Positron Emission Tomography) tracers for diagnostic imaging.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.