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Atomfair 2-Fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)aniline C12H17BFNO2

Description 2-Fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (CAS No. 819058-34-9) is a high-purity boronic ester derivative with the molecular formula C12H17BFNO2. This compound features a fluorinated aniline core coupled with a pinacol boronate ester group, making it a versatile intermediate for Suzuki-Miyaura cross-coupling reactions and other transition-metal-catalyzed transformations. Its well-defined structure (IUPAC name: 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline) ensures consistent reactivity, while the electron-withdrawing fluorine and electron-donating amino group enable precise tuning in pharmaceutical and materials science applications. Supplied as a crystalline solid with ??95% purity (HPLC), it is ideal for synthesizing fluorinated biaryl compounds, OLED materials, and bioactive molecules. Store under inert conditions to preserve stability.

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Description

Description

2-Fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (CAS No. 819058-34-9) is a high-purity boronic ester derivative with the molecular formula C12H17BFNO2. This compound features a fluorinated aniline core coupled with a pinacol boronate ester group, making it a versatile intermediate for Suzuki-Miyaura cross-coupling reactions and other transition-metal-catalyzed transformations. Its well-defined structure (IUPAC name: 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline) ensures consistent reactivity, while the electron-withdrawing fluorine and electron-donating amino group enable precise tuning in pharmaceutical and materials science applications. Supplied as a crystalline solid with ??95% purity (HPLC), it is ideal for synthesizing fluorinated biaryl compounds, OLED materials, and bioactive molecules. Store under inert conditions to preserve stability.

  • CAS No: 819058-34-9
  • Molecular Formula: C12H17BFNO2
  • Molecular Weight: 237.08
  • Exact Mass: 237.1336371
  • Monoisotopic Mass: 237.1336371
  • IUPAC Name: 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline
  • SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CC(=C(C=C2)N)F
  • Synonyms: 2-fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)aniline, 690-889-7, 819058-34-9, 4-Amino-3-fluorophenylboronic acid pinacol ester, 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

Application

This compound serves as a key building block in medicinal chemistry for introducing fluorinated aryl motifs into drug candidates, enhancing metabolic stability. It is widely used in Suzuki couplings to create conjugated systems for organic electronics, such as emissive layers in OLEDs. The amino group also allows further functionalization via amidation or diazotization, expanding its utility in agrochemical and polymer research.

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