Description

2-Fluoro-4-nitrotoluene (CAS: 1427-07-2) is a high-purity aromatic compound with the molecular formula C₇H₆FNO₂. This fine chemical is widely utilized in organic synthesis, pharmaceutical research, and agrochemical development due to its unique fluorinated nitroaromatic structure. The product is supplied as a crystalline solid or solution, with a purity of ≥98% (GC), ensuring reliable performance in demanding applications. Its reactive nitro and fluoro groups make it a valuable intermediate for nucleophilic substitution reactions, cross-coupling chemistry, and heterocycle formation. Proper storage at 2-8°C in a tightly sealed container is recommended to maintain stability.

Key Features:

• CAS: 1427-07-2 | Molecular Weight: 155.13 g/mol
• High purity (≥98%) by GC analysis
• Reactive sites for diverse functionalization
• Compatible with standard organic solvents
• Technical data sheet and COA available upon request

Properties

• CAS Number: 1427-07-2
• Complexity: 157
• IUPAC Name: 2-fluoro-1-methyl-4-nitro-benzene
• InChI: InChI=1S/C7H6FNO2/c1-5-2-3-6(9(10)11)4-7(5)8/h2-4H,1H3
• InChI Key: WIQISTBTOQNVCE-UHFFFAOYSA-N
• Exact Mass: 155.03825660
• Molecular Formula: C7H6FNO2
• Molecular Weight: 155.13
• SMILES: CC1=C(C=C(C=C1)[N+](=O)[O-])F
• Topological: 45.8
• Monoisotopic Mass: 155.03825660
• Synonyms: 2-Fluoro-4-nitrotoluene, 1427-07-2, 2-Fluoro-1-methyl-4-nitrobenzene, EINECS 215-845-2, WIQISTBTOQNVCE-UHFFFAOYSA-, DTXSID40162131, NSC 60724, DTXCID2084622, 215-845-2, inchi=1/c7h6fno2/c1-5-2-3-6(9(10)11)4-7(5)8/h2-4h,1h3, Benzene, 2-fluoro-1-methyl-4-nitro-, Toluene, 2-fluoro-4-nitro-, 3-Fluoro-4-methylnitrobenzene, 1-Methyl-2-fluoro-4-nitrobenzene, NSC-60724, 2-fluoro-1-methyl-4-nitro-benzene, NSC60724, MFCD00007199, 2-fluoro4-nitrotoluene, 2Fluoro 4Nitro Toluene, 2-Fluor-4-nitro-toluol, 2-fluoro-4-nitro toluene, 2- Fluoro-4-nitrotoluene, CSP7NA3X52, SCHEMBL171927, SCHEMBL5839662, SCHEMBL6098938, SCHEMBL6098941, SCHEMBL27807540, 2-Fluoro-4-nitrotoluene, 98%, BCP24544, CL9288, SBB063449, 2-Fluoro-1-methyl-4-nitrobenzene #, AKOS005145652, AC-2486, AS-12011, DB-023739, CS-0019446, F0292, NS00044634, ST51038067, EN300-64538, Z992934732

2-Fluoro-4-nitrotoluene serves as a key building block in medicinal chemistry for developing fluorinated pharmaceutical compounds. Researchers employ it as a precursor in Suzuki-Miyaura cross-coupling reactions to create biaryl structures. The compound’s electron-withdrawing groups facilitate nucleophilic aromatic substitutions in agrochemical synthesis. It’s also valuable in materials science for synthesizing advanced fluorinated polymers and liquid crystals.

Safety and Hazards

GHS Hazard Statements

• H228 (85.1%): Flammable solid [Danger Flammable solids]
• H302 (97.9%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (97.9%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (95.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (95.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (97.9%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (93.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P240, P241, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P405, and P501

Hazard Classes and Categories

• Flam. Sol. 2 (85.1%)
• Acute Tox. 4 (97.9%)
• Acute Tox. 4 (97.9%)
• Skin Irrit. 2 (95.7%)
• Eye Irrit. 2A (95.7%)
• Acute Tox. 4 (97.9%)
• STOT SE 3 (93.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.