Description

2-Fluoro-4-nitrophenol (CAS No. 403-19-0) is a high-purity fluorinated nitrophenol derivative with the molecular formula C₆H₄FNO₃. This compound is a versatile building block in organic synthesis, particularly in pharmaceutical and agrochemical research. Its unique structure, featuring both fluorine and nitro functional groups on a phenolic ring, enables selective reactivity for electrophilic aromatic substitution and nucleophilic displacement reactions. Available in >98% purity (HPLC), this product is rigorously tested for consistency and suitability in sensitive applications. Packaged under inert gas to ensure stability, it is ideal for use as an intermediate in the development of active pharmaceutical ingredients (APIs), dyes, and advanced materials. Store in a cool, dry place away from light and oxidizing agents.

Properties

• CAS Number: 403-19-0
• Complexity: 158
• IUPAC Name: 2-fluoro-4-nitro-phenol
• InChI: InChI=1S/C6H4FNO3/c7-5-3-4(8(10)11)1-2-6(5)9/h1-3,9H
• InChI Key: ORPHLVJBJOCHBR-UHFFFAOYSA-N
• Exact Mass: 157.01752115
• Molecular Formula: C6H4FNO3
• Molecular Weight: 157.10
• SMILES: C1=CC(=C(C=C1[N+](=O)[O-])F)O
• Topological: 66.1
• Monoisotopic Mass: 157.01752115
• Physical Description: Off-white or light brown solid;
• Vapor Pressure: 0.0026 [mmHg]
• Synonyms: 2-FLUORO-4-NITROPHENOL, 403-19-0, Phenol, 2-fluoro-4-nitro-, DTXSID7075393, Phenol, 2fluoro4nitro, DTXCID8039748, 628-527-7, 4-nitro-2-fluorophenol, MFCD00051970, 3-Fluoro-4-hydroxynitrobenzene, 2-fluoro-4-nitro-phenol, 2-Fluoro-4-nitrophenol potassium salt, 2-fluoro-4-nitro phenol, 21571-34-6, SCHEMBL105216, CHEMBL236536, SCHEMBL3029469, SR-1C6, 2-Fluoro-4-nitrophenol, 99%, BCP21663, SBB063133, AKOS005063932, AKOS034830320, AC-3029, CS-W004708, FF14224, GS-3016, DB-024007, F0381, ST51038199, EN300-40157, Z382708858, InChI=1/C6H4FNO3/c7-5-3-4(8(10)11)1-2-6(5)9/h1-3,9

Application

2-Fluoro-4-nitrophenol is widely used as a key intermediate in the synthesis of fluorinated pharmaceuticals and agrochemicals. Its nitro group facilitates further functionalization via reduction or coupling reactions, while the fluorine atom enhances metabolic stability in drug candidates. Researchers employ this compound in the development of dyes, liquid crystals, and corrosion inhibitors. It also serves as a precursor for Suzuki-Miyaura cross-coupling reactions in material science.

Safety and Hazards

GHS Hazard Statements

• H302 (98%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (87.8%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (98%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (87.8%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (98%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (98%)
• Acute Tox. 4 (87.8%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (98%)
• Acute Tox. 4 (87.8%)
• STOT SE 3 (98%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.