Description

2-Fluoro-4-methylpyridine (CAS No. 461-87-0) is a high-purity fluorinated pyridine derivative widely used in pharmaceutical, agrochemical, and material science research. With the molecular formula C₆H₆FN, this compound serves as a versatile building block for synthesizing complex molecules due to its reactive fluorine and methyl substituents. Our product is rigorously tested to ensure ≥98% purity, making it ideal for precision applications in medicinal chemistry and catalysis. Packaged under inert conditions to maintain stability, it is available in various quantities to suit laboratory and industrial-scale needs. Suitable for use in cross-coupling reactions, nucleophilic substitutions, and as a ligand precursor.

Properties

• CAS Number: 461-87-0
• Complexity: 74.9
• IUPAC Name: 2-fluoro-4-methyl-pyridine
• InChI: InChI=1S/C6H6FN/c1-5-2-3-8-6(7)4-5/h2-4H,1H3
• InChI Key: ZBFAXMKJADVOGH-UHFFFAOYSA-N
• Exact Mass: 111.048427358
• Molecular Formula: C6H6FN
• Molecular Weight: 111.12
• SMILES: CC1=CC(=NC=C1)F
• Topological: 12.9
• Monoisotopic Mass: 111.048427358
• Synonyms: 2-Fluoro-4-methylpyridine, 461-87-0, ZBFAXMKJADVOGH-UHFFFAOYSA-, DTXSID90372041, DTXCID50323074, 625-585-5, inchi=1/c6h6fn/c1-5-2-3-8-6(7)4-5/h2-4h,1h3, zbfaxmkjadvogh-uhfffaoysa-n, 2-Fluoro-4-picoline, 2-fluoro-4-methyl-pyridine, MFCD00041224, Pyridine, 2-fluoro-4-methyl-, 4-methyl-2-fluoropyridine, 2-fluoro-4-methyl pyridine, 2-Fluoro-4-methylpyridine (2-Fluoro-4-picoline), SCHEMBL11982, SCHEMBL596463, SCHEMBL1097939, SCHEMBL2371588, SCHEMBL16279990, 2-Fluoro-4-methylpyridine, 98%, BCP22114, AC-451, SBB054405, AKOS005063631, AB01854, CS-W011273, PS-9257, BP-21203, DB-025180, F0579, EN300-91300, C91259

2-Fluoro-4-methylpyridine is a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) and agrochemicals. Its fluoropyridine core is instrumental in developing fluorinated analogs for drug discovery programs. Researchers utilize this compound in Suzuki-Miyaura and other cross-coupling reactions to introduce fluorinated pyridine motifs into target molecules. It also finds use in material science for designing advanced polymers and ligands.

Safety and Hazards

GHS Hazard Statements

• H226 (16%): Flammable liquid and vapor [Warning Flammable liquids]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (98%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (16%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (98%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.