Description

2-Fluoro-4-methylbenzaldehyde (CAS No. 146137-80-6) is a high-purity aromatic aldehyde derivative with the molecular formula C₈H₇FO. This compound features a fluorine substituent at the 2-position and a methyl group at the 4-position of the benzaldehyde ring, offering unique reactivity for electrophilic aromatic substitution and nucleophilic addition reactions. Ideal for pharmaceutical intermediates, agrochemical synthesis, and advanced material research, this reagent is supplied as a clear to pale-yellow liquid with ≥95% purity (GC). Store under inert conditions at 2-8°C to prevent degradation. Suitable for use in Suzuki couplings, Grignard reactions, and as a building block for fluorinated liquid crystals.

Properties

• CAS Number: 146137-80-6
• Complexity: 124
• IUPAC Name: 2-fluoro-4-methyl-benzaldehyde
• InChI: InChI=1S/C8H7FO/c1-6-2-3-7(5-10)8(9)4-6/h2-5H,1H3
• InChI Key: MVDRIMBGRZBWPE-UHFFFAOYSA-N
• Exact Mass: 138.048093005
• Molecular Formula: C8H7FO
• Molecular Weight: 138.14
• SMILES: CC1=CC(=C(C=C1)C=O)F
• Topological: 17.1
• Monoisotopic Mass: 138.048093005
• Synonyms: 2-Fluoro-4-methylbenzaldehyde, 146137-80-6, DTXSID80380958, DTXCID60331983, 676-421-4, Benzaldehyde, 2-fluoro-4-methyl-, MFCD03094325, 2-fluoro-4-methyl-benzaldehyde, 2-FLUORO-P-TOLUALDEHYDE, 3-Fluoro-4-formyltoluene, 4-methyl-2-fluorobenzaldehyde, SCHEMBL364414, SCHEMBL21201424, MVDRIMBGRZBWPE-UHFFFAOYSA-N, BBL100793, SBB063769, STL554587, AKOS005063636, AC-3843, CS-W016507, FF69952, PS-9084, SY003457, DB-005240, EN300-125419, Z732814038

Application

2-Fluoro-4-methylbenzaldehyde serves as a versatile intermediate in organic synthesis, particularly in the preparation of fluorinated pharmaceuticals and agrochemicals. Its electron-withdrawing fluorine group enhances reactivity in palladium-catalyzed cross-coupling reactions, making it valuable for constructing complex aromatic systems. Researchers also utilize this compound in the development of liquid crystal materials due to its rigid, polarizable structure.

Safety and Hazards

GHS Hazard Statements

• H302 (30%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (30%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (30%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (30%)
• Acute Tox. 4 (30%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 4 (30%)
• STOT SE 3 (100%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.