Description

2-Fluoro-4-methylaniline (CAS No. 452-80-2) is a high-purity fluorinated aromatic amine with the molecular formula C₇H₈FN. This compound is a valuable intermediate in organic synthesis, particularly in the development of pharmaceuticals, agrochemicals, and specialty chemicals. Its unique structure, featuring both a fluorine substituent and a methyl group on the aniline ring, enhances reactivity and selectivity in coupling reactions, diazotization, and other functionalization processes. Ideal for researchers and industrial chemists, our product is rigorously tested to ensure ≥98% purity (GC), with trace metals and moisture levels minimized for sensitive applications. Available in sealed glass vials or bulk quantities under inert atmosphere to maintain stability.

Properties

• CAS Number: 452-80-2
• Complexity: 94.9
• IUPAC Name: 2-fluoro-4-methyl-aniline
• InChI: InChI=1S/C7H8FN/c1-5-2-3-7(9)6(8)4-5/h2-4H,9H2,1H3
• InChI Key: ZQEXBVHABAJPHJ-UHFFFAOYSA-N
• Exact Mass: 125.064077422
• Molecular Formula: C7H8FN
• Molecular Weight: 125.14
• SMILES: CC1=CC(=C(C=C1)N)F
• Topological: 26
• Monoisotopic Mass: 125.064077422
• Synonyms: 2-Fluoro-4-methylaniline, 452-80-2, Benzenamine, 2-fluoro-4-methyl-, NSC 147489, BRN 2637578, DTXSID40196431, DTXCID50118922, Benzenamine, 2-fluoro-4-methyl-(9CI), 610-237-7, 4-12-00-01981 (beilstein handbook reference), zqexbvhabajphj-uhfffaoysa-n, 2-fluoro-4-methyaniline, 2-Fluoro-p-toluidine, 4-Amino-3-fluorotoluene, p-Toluidine, 2-fluoro-, MFCD00040975, 2-fluoro-4-methylphenylamine, (2-fluoro-4-methylphenyl)amine, NSC-147489, 2-fluoro-4-methyl aniline, 2-fluoro-4-methyl-aniline, NSC147489, Benzenamine, 2-fluoro-4-methyl- (9CI), 2-fluoro4-methylaniline, 4-methyl-2-fluoroaniline, 6-fluoro-4-methylaniline, WLN: ZR BF D1, SCHEMBL17613, 2-fluoro-4-methylbenzenamine, SCHEMBL653190, SCHEMBL6085883, Z6EGC62G32, SCHEMBL10509555, SCHEMBL17023607, 2-Fluoro-4-methylaniline, 99%, CK1162, SBB006650, STL169021, AKOS000120472, AC-3686, CS-W013515, PS-9198, SB40474, DB-024066, F0529, NS00127306, ST51038189, EN300-20297, Z104477648

Application

2-Fluoro-4-methylaniline is widely used as a building block in pharmaceutical synthesis, particularly for fluorinated drug candidates targeting CNS and antimicrobial therapies. It serves as a precursor in the production of dyes, pigments, and liquid crystals due to its electron-withdrawing fluorine group. The compound is also employed in agrochemical research for developing herbicides and pesticides with enhanced metabolic stability.

Safety and Hazards

GHS Hazard Statements

• H301 (89.6%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302 (10.4%): Harmful if swallowed [Warning Acute toxicity, oral]
• H311 (95.8%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H315 (97.9%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (97.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H331 (85.4%): Toxic if inhaled [Danger Acute toxicity, inhalation]
• H332 (10.4%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (85.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H373 (10.4%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Precautionary Statements

• P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (89.6%)
• Acute Tox. 4 (10.4%)
• Acute Tox. 3 (95.8%)
• Skin Irrit. 2 (97.9%)
• Eye Irrit. 2 (97.9%)
• Acute Tox. 3 (85.4%)
• Acute Tox. 4 (10.4%)
• STOT SE 3 (85.4%)
• STOT RE 2 (10.4%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.