Description

2-Fluoro-3-nitropyridine (CAS No. 1480-87-1) is a high-purity fluorinated nitropyridine derivative, widely utilized in pharmaceutical and agrochemical research. With the molecular formula C₅H₃FN₂O₂, this compound serves as a versatile intermediate in organic synthesis, particularly in the development of novel bioactive molecules. Its unique structure, featuring both fluorine and nitro functional groups, enables selective reactivity for cross-coupling reactions, nucleophilic substitutions, and other advanced transformations. Packaged under strict quality control, our 2-Fluoro-3-nitropyridine is ideal for researchers requiring consistent performance in medicinal chemistry, material science, and specialty chemical applications.

Key Features:

• High chemical purity (>98%)
• Stable under recommended storage conditions
• Compatible with a broad range of synthetic protocols
• Available in customizable quantities for lab-scale to industrial use

Properties

• CAS Number: 1480-87-1
• Complexity: 136
• IUPAC Name: 2-fluoro-3-nitro-pyridine
• InChI: InChI=1S/C5H3FN2O2/c6-5-4(8(9)10)2-1-3-7-5/h1-3H
• InChI Key: QDKIYDGHCFZBGC-UHFFFAOYSA-N
• Exact Mass: 142.01785550
• Molecular Formula: C5H3FN2O2
• Molecular Weight: 142.09
• SMILES: C1=CC(=C(N=C1)F)[N+](=O)[O-]
• Topological: 58.7
• Monoisotopic Mass: 142.01785550
• Synonyms: 2-Fluoro-3-nitropyridine, 1480-87-1, DTXSID40376478, DTXCID40327506, 675-588-0, Pyridine, 2-fluoro-3-nitro-, 2-fluoro-3-nitro-pyridine, MFCD03095068, 2-fluor-3-nitropyridine, 3-Nitro-2-fluoropyridine, SCHEMBL251800, QDKIYDGHCFZBGC-UHFFFAOYSA-N, BCP22086, CS-D0967, SBB068995, AKOS005255936, AC-6000, AS-14963, DB-028058, F0982, EN300-41103

2-Fluoro-3-nitropyridine is primarily employed as a building block in the synthesis of fluorinated pharmaceuticals and agrochemicals. Its reactivity facilitates the introduction of fluorine into heterocyclic scaffolds, enhancing metabolic stability and bioavailability in drug candidates. Researchers also leverage this compound for developing fluorescent probes and advanced materials. Suitable for Suzuki-Miyaura couplings and SNAr reactions, it is a staple in medicinal chemistry workflows.

Safety and Hazards

GHS Hazard Statements

• H302 (60%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (20%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (20%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (80%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (60%)
• Acute Tox. 4 (20%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 4 (20%)
• STOT SE 3 (80%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.