Description

2-Fluoro-3-nitrobenzyl alcohol (CAS No. 946126-95-0) is a high-purity fluorinated nitroaromatic compound with the molecular formula C₇H₆FNO₃. This fine chemical, also known by its IUPAC name (2-fluoro-3-nitrophenyl)methanol, is a versatile building block in organic synthesis and pharmaceutical research. The compound features a benzyl alcohol group ortho to both a fluorine substituent and a nitro group, making it a valuable intermediate for nucleophilic aromatic substitution reactions and further functionalization.

Our product is synthesized under strict quality control measures to ensure >98% purity (HPLC) and is supplied as a crystalline solid with excellent batch-to-batch consistency. The material is carefully packaged under inert atmosphere to maintain stability and is available in research quantities from milligrams to kilogram scale. Technical data including ¹H/¹³C NMR spectra, HPLC chromatograms, and MSDS are available upon request.

Storage recommendations: Keep container tightly closed in a dry and well-ventilated place at 2-8°C. Protect from light and moisture.

Properties

• CAS Number: 946126-95-0
• Complexity: 171
• IUPAC Name: (2-fluoro-3-nitro-phenyl)methanol
• InChI: InChI=1S/C7H6FNO3/c8-7-5(4-10)2-1-3-6(7)9(11)12/h1-3,10H,4H2
• InChI Key: OWEPNYHVJVFJRO-UHFFFAOYSA-N
• Exact Mass: 171.03317122
• Molecular Formula: C7H6FNO3
• Molecular Weight: 171.13
• SMILES: C1=CC(=C(C(=C1)[N+](=O)[O-])F)CO
• Topological: 66.1
• Monoisotopic Mass: 171.03317122
• Synonyms: 2-FLUORO-3-NITROBENZYL ALCOHOL, 810-864-8, (2-Fluoro-3-nitrophenyl)methanol, 946126-95-0, BENZENEMETHANOL,2-FLUORO-3-NITRO-, 2-FLUORO-3-NITROBENZYLALCOHOL, MFCD09835208, SCHEMBL961175, SCHEMBL16952150, DTXSID30652096, (3-nitro-2-fluorophenyl)methanol, OWEPNYHVJVFJRO-UHFFFAOYSA-N, (2-fluoro-3-nitro-phenyl)methanol, AKOS006327697, CS-W021063, DS-0581, DB-079977, EN300-1841134, 2-fluoro-3-nitro-benzenemethanol,;(2-Fluoro-3-nitrophenyl)methanol

Application

2-Fluoro-3-nitrobenzyl alcohol serves as a key intermediate in the synthesis of fluorinated pharmaceutical compounds and agrochemicals. The compound’s reactive sites allow for selective modification of the aromatic ring, making it valuable for creating analogs in drug discovery programs. Researchers utilize this building block in the development of kinase inhibitors and other biologically active molecules where the fluorine-nitro substitution pattern is pharmacologically relevant.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.