Description

2-Fluoro-3-methylbenzoic acid (CAS: 315-31-1) is a high-purity fluorinated aromatic carboxylic acid with the molecular formula C₈H₇FO₂. This compound is a versatile building block in organic synthesis, particularly in pharmaceutical and agrochemical research, due to its reactive carboxyl group and fluorine substitution. It is supplied as a white to off-white crystalline powder with ≥98% purity (HPLC), ensuring optimal performance in sensitive applications. Suitable for use in coupling reactions, ligand synthesis, and as a precursor for bioactive molecules, this product is rigorously tested for consistency and quality. Packaged under inert conditions to enhance stability, it is ideal for researchers requiring reliable fluorinated intermediates.

Properties

• CAS Number: 315-31-1
• Complexity: 158
• IUPAC Name: 2-fluoro-3-methyl-benzoic acid
• InChI: InChI=1S/C8H7FO2/c1-5-3-2-4-6(7(5)9)8(10)11/h2-4H,1H3,(H,10,11)
• InChI Key: DGNAETGARNTCIL-UHFFFAOYSA-N
• Exact Mass: 154.04300762
• Molecular Formula: C8H7FO2
• Molecular Weight: 154.14
• SMILES: CC1=C(C(=CC=C1)C(=O)O)F
• Topological: 37.3
• Monoisotopic Mass: 154.04300762
• Synonyms: 2-Fluoro-3-methylbenzoic acid, 315-31-1, DTXSID90372026, DTXCID50323059, 630-016-9, 2-Fluoro-3-methylbenzoicacid, MFCD00042504, 2-Fluoro-m-toluic acid, Benzoic acid, 2-fluoro-3-methyl-, Maybridge1_003142, fluoro-3-methylbenzoic acid, SCHEMBL698709, 3-methyl-2-fluorobenzoic acid, SCHEMBL7497102, 2-Fluoro-3-methyl benzoic acid, SCHEMBL18547475, HMS550G18, DGNAETGARNTCIL-UHFFFAOYSA-N, 2-fluoranyl-3-methyl-benzoic acid, CCG-55063, CL8044, SBB062991, AKOS005257147, AC-3975, CS-W018051, FF71229, FS-2135, SY014074, DB-006116, A4898, F0949, EN300-97685, A808510, SR-01000644112-1, Z1201617985

2-Fluoro-3-methylbenzoic acid is widely used as a key intermediate in the synthesis of fluorinated pharmaceuticals and specialty chemicals. Its applications include serving as a precursor in the development of kinase inhibitors and other bioactive compounds. Researchers also employ it in cross-coupling reactions to introduce fluorine-containing aromatic motifs into complex molecules. Additionally, it finds use in material science for modifying polymer properties. The compound’s stability and reactivity make it valuable for both small-scale laboratory experiments and industrial-scale production.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (88.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (88.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.