Description

2-Fluoro-3-methylaniline (CAS No. 1978-33-2) is a high-purity fluorinated aromatic amine with the molecular formula C₇H₈FN. This specialized organic compound is characterized by a fluorine substituent at the ortho position and a methyl group at the meta position relative to the aniline nitrogen. Ideal for pharmaceutical intermediates, agrochemical synthesis, and advanced material research, our product is rigorously tested to ensure ≥98% purity (GC) with controlled moisture content. Supplied in amber glass bottles under inert atmosphere to prevent degradation. Key spectral data (HPLC, NMR, MS) available upon request. Hazard classification: Acute Tox. 4 (Oral), Skin Sens. 1.

Properties

• CAS Number: 1978-33-2
• Complexity: 94.9
• IUPAC Name: 2-fluoro-3-methyl-aniline
• InChI: InChI=1S/C7H8FN/c1-5-3-2-4-6(9)7(5)8/h2-4H,9H2,1H3
• InChI Key: WFZUBZAEFXETBF-UHFFFAOYSA-N
• Exact Mass: 125.064077422
• Molecular Formula: C7H8FN
• Molecular Weight: 125.14
• SMILES: CC1=C(C(=CC=C1)N)F
• Topological: 26
• Monoisotopic Mass: 125.064077422
• Synonyms: 2-Fluoro-3-methylaniline, 1978-33-2, DTXSID00627933, DTXCID30578686, 675-536-7, 3-amino-2-fluorotoluene, 2-Fluoro-m-toluidine, BENZENAMINE, 2-FLUORO-3-METHYL-, 2-fluoro-3-methylbenzenamine, MFCD06410915, 2-fluoro-3-methylphenylamine, SCHEMBL406513, 2-Fluoro-3-methyl-phenylamine, SCHEMBL1550874, SCHEMBL17023613, SBB069825, AKOS005145718, AB25121, AC-3378, CS-W003289, FF32692, PS-9199, SY018333, DB-005270, F0554, EN300-126352, 3-Amino-2-fluorotoluene;2-fluoro-3-aminotoluene

Application

2-Fluoro-3-methylaniline serves as a key building block in the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and CNS-targeting drugs. The compound’s unique substitution pattern enables regioselective coupling reactions in palladium-catalyzed cross-coupling methodologies. Researchers also utilize this aniline derivative in the development of liquid crystal materials and as a precursor for fluorinated dyes with enhanced photostability.

Safety and Hazards

GHS Hazard Statements

• H227 (25%): Combustible liquid [Warning Flammable liquids]
• H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (50%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (50%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403, P403+P233, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 4 (25%)
• Acute Tox. 4 (50%)
• Acute Tox. 4 (50%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 4 (50%)
• STOT SE 3 (50%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.