Description

2-Fluoro-3-methoxyphenylboronic acid (CAS No. 352303-67-4) is a high-purity boronic acid derivative with the molecular formula C₇H₈BFO₃. This compound, also known by its IUPAC name (2-fluoro-3-methoxyphenyl)boronic acid, is a valuable building block in organic synthesis and pharmaceutical research. Its unique structure, featuring both fluorine and methoxy substituents on the phenyl ring, makes it a versatile reagent for Suzuki-Miyaura cross-coupling reactions, enabling the formation of biaryl compounds with high selectivity. The product is supplied as a white to off-white crystalline powder with ≥95% purity (HPLC), ensuring optimal performance in sensitive applications. It is stable under recommended storage conditions (2-8°C, inert atmosphere) and should be handled with care to avoid moisture exposure. Ideal for researchers in medicinal chemistry, materials science, and catalysis.

Properties

• CAS Number: 352303-67-4
• Complexity: 145
• IUPAC Name: (2-fluoro-3-methoxy-phenyl)boronic acid
• InChI: InChI=1S/C7H8BFO3/c1-12-6-4-2-3-5(7(6)9)8(10)11/h2-4,10-11H,1H3
• InChI Key: JCKZNMSBFBPDPM-UHFFFAOYSA-N
• Exact Mass: 170.0550524
• Molecular Formula: C7H8BFO3
• Molecular Weight: 169.95
• SMILES: B(C1=C(C(=CC=C1)OC)F)(O)O
• Topological: 49.7
• Monoisotopic Mass: 170.0550524
• Synonyms: 2-Fluoro-3-methoxyphenylboronic acid, 352303-67-4, DTXSID60407258, BORONIC ACID, B-(2-FLUORO-3-METHOXYPHENYL)-, DTXCID60358110, 609-099-0, (2-fluoro-3-methoxyphenyl)boronic acid, 2-fluoro-3-methoxybenzeneboronic acid, Boronic acid, (2-fluoro-3-methoxyphenyl)-, MFCD02094728, C42SY4A63V, Elagolix intermediate, (3-Methoxy-2-fluorophenyl)boronic acid, B-(2-Fluoro-3-methoxyphenyl)boronic acid, (2-Fluoro-3-Methoxyphenyl)Boranediol, 2-fluoro-3-methoxyphenyl boronic acid, UNII-C42SY4A63V, SCHEMBL126401, BCP29025, SBB052541, (2-fluoro-3-methoxyphenyl)boronicacid, 2-fluoro-3-methoxy-phenylboronic acid, AKOS005254274, AB10917, CS-W020414, PS-9568, 2-fluoro-3-methoxy-phenyl-boronic acid, AC-31337, FF104841, HY-32923, SY025630, DB-028056, F0940, EN300-755153, Z1203162315, (2-fluoro-3-methoxyphenyl)boronic acid pound>>(2-fluoro-3-methoxy-phenyl)boronic Acid, 2-Fluoro-3-methoxybenzeneboronic Acid (contains varying amounts of Anhydride)

Application

2-Fluoro-3-methoxyphenylboronic acid is widely used as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and advanced materials. Its fluorine and methoxy groups enhance electronic properties, making it valuable for designing bioactive molecules. The compound is particularly useful in Suzuki-Miyaura cross-coupling reactions to create complex biaryl structures. Researchers also employ it in the development of boron-based sensors and catalysts.

Safety and Hazards

GHS Hazard Statements

• H302 (25%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (66.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (75%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (58.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (25%)
• Skin Irrit. 2 (66.7%)
• Eye Irrit. 2A (75%)
• STOT SE 3 (58.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.