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Atomfair 2-Fluoro-3-methoxyphenylboronic acid C7H8BFO3 CAS 352303-67-4

2-Fluoro-3-methoxyphenylboronic acid (CAS No. 352303-67-4) is a high-purity boronic acid derivative with the molecular formula C7H8BFO3. This compound, also known by its IUPAC name (2-fluoro-3-methoxyphenyl)boronic acid , is a valuable building block in organic synthesis and pharmaceutical research. Its unique structure, featuring both fluorine and methoxy substituents on the phenyl ring, makes it a versatile reagent for Suzuki-Miyaura cross-coupling reactions, enabling the formation of biaryl compounds with high selectivity. The product is supplied as a white to off-white crystalline powder with ≥95% purity (HPLC), ensuring optimal performance in sensitive applications. It is stable under recommended storage conditions (2-8°C, inert atmosphere)…

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Description

2-Fluoro-3-methoxyphenylboronic acid (CAS No. 352303-67-4) is a high-purity boronic acid derivative with the molecular formula C7H8BFO3. This compound, also known by its IUPAC name (2-fluoro-3-methoxyphenyl)boronic acid, is a valuable building block in organic synthesis and pharmaceutical research. Its unique structure, featuring both fluorine and methoxy substituents on the phenyl ring, makes it a versatile reagent for Suzuki-Miyaura cross-coupling reactions, enabling the formation of biaryl compounds with high selectivity. The product is supplied as a white to off-white crystalline powder with ≥95% purity (HPLC), ensuring optimal performance in sensitive applications. It is stable under recommended storage conditions (2-8°C, inert atmosphere) and should be handled with care to avoid moisture exposure. Ideal for researchers in medicinal chemistry, materials science, and catalysis.

Properties

  • CAS Number: 352303-67-4
  • Complexity: 145
  • IUPAC Name: (2-fluoro-3-methoxy-phenyl)boronic acid
  • InChI: InChI=1S/C7H8BFO3/c1-12-6-4-2-3-5(7(6)9)8(10)11/h2-4,10-11H,1H3
  • InChI Key: JCKZNMSBFBPDPM-UHFFFAOYSA-N
  • Exact Mass: 170.0550524
  • Molecular Formula: C7H8BFO3
  • Molecular Weight: 169.95
  • SMILES: B(C1=C(C(=CC=C1)OC)F)(O)O
  • Topological: 49.7
  • Monoisotopic Mass: 170.0550524
  • Synonyms: 2-Fluoro-3-methoxyphenylboronic acid, 352303-67-4, DTXSID60407258, BORONIC ACID, B-(2-FLUORO-3-METHOXYPHENYL)-, DTXCID60358110, 609-099-0, (2-fluoro-3-methoxyphenyl)boronic acid, 2-fluoro-3-methoxybenzeneboronic acid, Boronic acid, (2-fluoro-3-methoxyphenyl)-, MFCD02094728, C42SY4A63V, Elagolix intermediate, (3-Methoxy-2-fluorophenyl)boronic acid, B-(2-Fluoro-3-methoxyphenyl)boronic acid, (2-Fluoro-3-Methoxyphenyl)Boranediol, 2-fluoro-3-methoxyphenyl boronic acid, UNII-C42SY4A63V, SCHEMBL126401, BCP29025, SBB052541, (2-fluoro-3-methoxyphenyl)boronicacid, 2-fluoro-3-methoxy-phenylboronic acid, AKOS005254274, AB10917, CS-W020414, PS-9568, 2-fluoro-3-methoxy-phenyl-boronic acid, AC-31337, FF104841, HY-32923, SY025630, DB-028056, F0940, EN300-755153, Z1203162315, (2-fluoro-3-methoxyphenyl)boronic acid pound>>(2-fluoro-3-methoxy-phenyl)boronic Acid, 2-Fluoro-3-methoxybenzeneboronic Acid (contains varying amounts of Anhydride)

Application

2-Fluoro-3-methoxyphenylboronic acid is widely used as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and advanced materials. Its fluorine and methoxy groups enhance electronic properties, making it valuable for designing bioactive molecules. The compound is particularly useful in Suzuki-Miyaura cross-coupling reactions to create complex biaryl structures. Researchers also employ it in the development of boron-based sensors and catalysts.

Safety and Hazards

GHS Hazard Statements

  • H302 (25%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H315 (66.7%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (75%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (58.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 4 (25%)
  • Skin Irrit. 2 (66.7%)
  • Eye Irrit. 2A (75%)
  • STOT SE 3 (58.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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