Description

2′-Deoxy-2′-fluorouridine (CAS: 784-71-4) is a fluorinated nucleoside analog with the molecular formula C₉H₁₁FN₂O₅. This compound, also known by its IUPAC name 1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione, is a modified uridine derivative where the 2′-hydroxyl group is replaced by a fluorine atom. It serves as a critical intermediate in nucleic acid research, antiviral drug development, and as a building block for oligonucleotide synthesis.

With high purity (>98%) and rigorous quality control, our 2′-Deoxy-2′-fluorouridine is ideal for researchers in medicinal chemistry, molecular biology, and pharmaceutical sciences. The compound is supplied as a white to off-white crystalline powder, soluble in water and DMSO, and is characterized by HPLC, NMR, and mass spectrometry for guaranteed consistency. Store at -20°C in a dry environment to ensure long-term stability.

Properties

• CAS Number: 784-71-4
• Complexity: 374
• IUPAC Name: 1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione
• InChI: InChI=1S/C9H11FN2O5/c10-6-7(15)4(3-13)17-8(6)12-2-1-5(14)11-9(12)16/h1-2,4,6-8,13,15H,3H2,(H,11,14,16)/t4-,6-,7-,8-/m1/s1
• InChI Key: UIYWFOZZIZEEKJ-XVFCMESISA-N
• Exact Mass: 246.06519962
• Molecular Formula: C9H11FN2O5
• Molecular Weight: 246.19
• SMILES: C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)F
• Topological: 99.1
• Monoisotopic Mass: 246.06519962
• Synonyms: 2′-Deoxy-2′-fluorouridine, 784-71-4, 2′-Fluoro-2′-deoxyuridine, Uridine, 2′-deoxy-2′-fluoro-, 2′-Deoxy-2′-fluoro-L-uridine, MFCD01317293, Y2YC903QW8, 1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione, 622785-69-7, 1-((2R,3R,4R,5R)-3-FLUORO-4-HYDROXY-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL)PYRIMIDINE-2,4(1H,3H)-DIONE, C9H11FN2O5, 2’Fluoro-2′-deoxyuridine, UNII-Y2YC903QW8, 2′-deoxy-2′-fluoro-uridine, 1-((2R,3R,4R,5R)-3-FLUORO-4-HYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL)PYRIMIDINE-2,4-DIONE, 1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione, 2′-deoxy-2′- fluorouridine, SCHEMBL221951, CHEMBL2385615, DTXSID50999738, UIYWFOZZIZEEKJ-XVFCMESISA-N, 2′-deoxy-2′-(R)-fluoro-uridine, HG1163, STK368458, AKOS015896926, CS-W014119, HY-W013403, ND06544, BP-58615, DA-49404, DA-60121, DS-10495, PD158307, ST50863923, 1-(2-deoxy-2-fluoro-beta-D-ribofuranosyl)uracil, Q27294189, 1-(2-DEOXY-2-FLUORO-.BETA,-D-RIBOFURANOSYL)URACIL, 1-(2-Deoxy-2-fluoropentofuranosyl)-4-hydroxypyrimidin-2(1H)-one, 1-(3-Fluoro-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione, 1-(2′-Fluoro-2′-deoxy-b-D-ribofuranosyl)uracil;2′-Deoxy-2′-fluoro-D-uridine;2′-Fluoro-2′-deoxyuridine, 1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-dihydrop yrimidine-2,4-dione

Application

2′-Deoxy-2′-fluorouridine is widely used in the synthesis of modified oligonucleotides for antisense and siRNA applications, where its fluorine substitution enhances nuclease resistance. It serves as a key precursor in the development of antiviral and anticancer nucleoside analogs, particularly for targeting RNA viruses. Researchers also employ it in structural studies to investigate the role of 2′-substituents in nucleic acid conformation and stability.

Safety and Hazards

GHS Hazard Statements

• H228 (50%): Flammable solid [Danger Flammable solids]

Precautionary Statements

• P210, P240, P241, P280, and P370+P378

Hazard Classes and Categories

• Flam. Sol. 2 (50%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.