Description

2′-Deoxy-2′-fluoroinosine (CAS: 80049-87-2) is a fluorinated nucleoside analog with the molecular formula C₁₀H₁₁FN₄O₄. This high-purity compound is specifically designed for advanced research applications in biochemistry, molecular biology, and medicinal chemistry. As a modified inosine derivative, it features a fluorine atom at the 2′-position of the ribose sugar, enhancing its stability and potential utility in nucleic acid studies, antiviral research, and enzyme inhibition assays. The product is supplied as a white to off-white crystalline powder with ≥95% purity (HPLC), ensuring reliable performance in sensitive experiments. It is soluble in DMSO and slightly soluble in water, making it suitable for a wide range of experimental conditions. Store at -20°C under inert conditions to maintain stability.

Properties

• CAS Number: 80049-87-2
• Complexity: 409
• IUPAC Name: 9-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-purin-6-one
• InChI: InChI=1S/C10H11FN4O4/c11-5-7(17)4(1-16)19-10(5)15-3-14-6-8(15)12-2-13-9(6)18/h2-5,7,10,16-17H,1H2,(H,12,13,18)/t4-,5-,7-,10-/m1/s1
• InChI Key: NRVOTDBYJXFINS-QYYRPYCUSA-N
• Exact Mass: 270.07643301
• Molecular Formula: C10H11FN4O4
• Molecular Weight: 270.22
• SMILES: C1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)F
• Topological: 109
• Monoisotopic Mass: 270.07643301
• Synonyms: 80049-87-2, 2′-Deoxy-2′-fluoroinosine, 2′-Dfin, Inosine, 2′-deoxy-2′-fluoro-, DTXSID90230051, DTXCID90152542, 2′-FLUORO-2′-DEOXYINOSINE, Inosine,2′-deoxy-2′-fluoro-, 2′-Deoxy-2′-fluoro-D-inosine, 9-[(2R,3R,4R,5R)-3-FLUORO-4-HYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-1H-PURIN-6-ONE, MFCD09750860, 9-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol, 2′-deoxy-2′-fluoro-inosine, SCHEMBL1061428, SCHEMBL9132895, CHEMBL3143525, C10H11FN4O4, 9-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-9H-purin-6-ol, NRVOTDBYJXFINS-QYYRPYCUSA-N, HG1193, AKOS037644236, ND06005, AS-49383, BP-43581, DA-60120, 9-(2-Deoxy-2-fluoro-beta-D-ribofuranosyl)hypoxanthine, 2′-Fluoro-2′-deoxy-D-inosine;2′-Deoxy-2′-fluoro-D-inosine;2′-Fluoro-2′-deoxyinosine, 9-(3-Fluoro-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1,9-dihydro-purin-6-one, 9-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-purin-6-one

2′-Deoxy-2′-fluoroinosine is widely used as a key intermediate in the synthesis of modified oligonucleotides for antisense and RNA interference studies. Its fluorinated ribose moiety enhances resistance to nucleases, making it valuable for probing nucleic acid structure-function relationships. Researchers also employ this compound in the development of antiviral and anticancer nucleoside analogs due to its ability to mimic natural substrates. Additionally, it serves as a tool compound in enzymatic studies targeting purine metabolism pathways.

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