Description

2-Cyano-4-methylpyridine (CAS No. 1620-76-4) is a high-purity organic compound with the molecular formula C₇H₆N₂ and IUPAC name 4-methylpyridine-2-carbonitrile. This versatile heterocyclic nitrile is widely utilized in pharmaceutical synthesis, agrochemical research, and material science applications. Our product is rigorously tested to ensure ≥98% purity (GC) and is supplied as a clear to pale yellow crystalline solid with a characteristic aromatic odor. Suitable for use as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) and specialty chemicals. Packaged under inert gas in amber glass bottles to ensure stability and longevity. Technical specifications include: molecular weight 118.14 g/mol, melting point 50-54°C, boiling point 250-252°C, and density 1.08 g/cm³. Store in a cool, dry place away from strong oxidizers.

Properties

• CAS Number: 1620-76-4
• Complexity: 133
• IUPAC Name: 4-methylpyridine-2-carbonitrile
• InChI: InChI=1S/C7H6N2/c1-6-2-3-9-7(4-6)5-8/h2-4H,1H3
• InChI Key: LQAWSWUFSHYCHP-UHFFFAOYSA-N
• Exact Mass: 118.053098200
• Molecular Formula: C7H6N2
• Molecular Weight: 118.14
• SMILES: CC1=CC(=NC=C1)C#N
• Topological: 36.7
• Monoisotopic Mass: 118.053098200
• Synonyms: 2-Cyano-4-methylpyridine, 4-Methyl-2-pyridinecarbonitrile, 627-197-1, 1620-76-4, 4-methylpicolinonitrile, 4-methylpyridine-2-carbonitrile, 2-PYRIDINECARBONITRILE, 4-METHYL-, MFCD00128868, 2-Cyano 4-methylpyridine, 2-cyano-4-methyl pyridine, 2-CYANO-4-PICOLINE, SCHEMBL91455, SCHEMBL131627, SCHEMBL2999285, SCHEMBL4756833, LQAWSWUFSHYCHP-UHFFFAOYSA-, 4-methyl-pyridine-2-carbonitrile, CL8875, SBB055617, AKOS002665643, 4-Methyl-2-pyridinecarbonitrile, 97%, AB03610, AC-5083, CS-W008101, PS-6146, SY019192, DB-020974, DB-358461, A3599, C2603, EN300-73457, 2-Cyano-4-methylpyridine (2-Cyano-4-picoline), Z1160863237, InChI=1/C7H6N2/c1-6-2-3-9-7(4-6)5-8/h2-4H,1H3

Application

2-Cyano-4-methylpyridine serves as a crucial building block in medicinal chemistry for the synthesis of pyridine-based drug candidates. This compound finds particular utility in the development of kinase inhibitors and central nervous system (CNS) active pharmaceuticals. Researchers employ it as a precursor for functionalized pyridine derivatives through nucleophilic substitution reactions. In material science, it acts as a ligand precursor for transition metal complexes. The methyl and cyano substituents offer multiple sites for further chemical modifications.

Safety and Hazards

GHS Hazard Statements

• H301 (91.1%): Toxic if swallowed [Danger Acute toxicity, oral]
• H315 (91.1%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (88.9%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (11.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (88.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (91.1%)
• Skin Irrit. 2 (91.1%)
• Eye Dam. 1 (88.9%)
• Eye Irrit. 2 (11.1%)
• STOT SE 3 (88.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.