Description

2-Cyano-3-fluoropyridine (CAS No. 97509-75-6) is a high-purity fluorinated pyridine derivative with the molecular formula C₆H₃FN₂. This compound, also known by its IUPAC name 3-fluoropyridine-2-carbonitrile, is a versatile building block in pharmaceutical and agrochemical synthesis. Its unique structure, featuring both a cyano (-CN) and a fluorine (-F) substituent on the pyridine ring, makes it a valuable intermediate for nucleophilic substitution reactions, cross-coupling chemistry, and heterocyclic scaffold development. Our product is rigorously tested to ensure ≥98% purity (HPLC/GC) and is supplied as a white to off-white crystalline solid with excellent batch-to-batch consistency. Suitable for medicinal chemistry, material science research, and as a precursor for fluorinated liquid crystals. Available in convenient packaging options from grams to kilograms with full analytical documentation (COA, MSDS, NMR).

Properties

• CAS Number: 97509-75-6
• Complexity: 137
• IUPAC Name: 3-fluoropyridine-2-carbonitrile
• InChI: InChI=1S/C6H3FN2/c7-5-2-1-3-9-6(5)4-8/h1-3H
• InChI Key: VZFPSCNTFBJZHB-UHFFFAOYSA-N
• Exact Mass: 122.02802627
• Molecular Formula: C6H3FN2
• Molecular Weight: 122.10
• SMILES: C1=CC(=C(N=C1)C#N)F
• Topological: 36.7
• Monoisotopic Mass: 122.02802627
• Synonyms: 2-Cyano-3-fluoropyridine, 97509-75-6, DTXSID40427611, DTXCID70378445, 627-335-0, 3-fluoropicolinonitrile, 3-fluoropyridine-2-carbonitrile, 3-fluoro-2-pyridinecarbonitrile, 3-fluoro-2-cyanopyridine, MFCD06797501, 2-Pyridinecarbonitrile, 3-fluoro-, fluorocyanopyridine, 2-cyano-3-fluoro-pyridine, SCHEMBL506689, SCHEMBL1149414, SCHEMBL17316908, SCHEMBL28586496, 2-Pyridinecarbonitrile,3-fluoro-, 3-fluoro-pyridine-2-carbonitrile, VZFPSCNTFBJZHB-UHFFFAOYSA-N, 3-fluoranylpyridine-2-carbonitrile, BCP07099, BBL103401, SBB065259, STL557211, AKOS005063483, 3-Fluoro-2-pyridinecarbonitrile, 96%, AC-5960, CS-W005247, FG-0475, PB17393, NCGC00382985-02, SY014411, DB-031996, C2655, EN300-102907, A845716, F8889-9368

Application

2-Cyano-3-fluoropyridine serves as a key intermediate in the synthesis of fluorinated pharmaceuticals, particularly for developing kinase inhibitors and CNS-active compounds. The fluorine atom enhances metabolic stability and bioavailability in drug candidates, while the cyano group allows for further functionalization through reduction or nucleophilic addition. This compound is also employed in materials science for creating fluorinated conductive polymers and as a precursor for specialty agrochemicals requiring pyridine-based active ingredients.

Safety and Hazards

GHS Hazard Statements

• H302 (95.8%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (87.5%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (85.4%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (14.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (87.5%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (89.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (95.8%)
• Acute Tox. 4 (87.5%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (85.4%)
• Eye Irrit. 2 (14.6%)
• Acute Tox. 4 (87.5%)
• STOT SE 3 (89.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.