Description

2-Chlorothiophene (CAS No. 96-43-5) is a high-purity heterocyclic organic compound with the molecular formula C₄H₃ClS. This colorless to pale yellow liquid is a versatile building block in organic synthesis, particularly in the pharmaceutical, agrochemical, and material science industries. Its reactive chlorinated thiophene structure makes it a valuable intermediate for cross-coupling reactions, such as Suzuki-Miyaura and Stille couplings. With a boiling point of 128-129°C and a density of 1.285 g/cm³, it is compatible with a wide range of solvents, including ether, THF, and DCM. Packaged under inert gas to ensure stability, our 2-Chlorothiophene is rigorously tested via GC, NMR, and HPLC to meet the highest purity standards (>98%). Ideal for researchers developing advanced heterocyclic compounds, conductive polymers, or bioactive molecules.

Properties

• CAS Number: 96-43-5
• Complexity: 46.8
• IUPAC Name: 2-chlorothiophene
• InChI: InChI=1S/C4H3ClS/c5-4-2-1-3-6-4/h1-3H
• InChI Key: GSFNQBFZFXUTBN-UHFFFAOYSA-N
• Exact Mass: 117.9643990
• Molecular Formula: C4H3ClS
• Molecular Weight: 118.59
• SMILES: C1=CSC(=C1)Cl
• Topological: 28.2
• Monoisotopic Mass: 117.9643990
• Synonyms: 2-CHLOROTHIOPHENE, 96-43-5, 2-Thienyl chloride, Thiophene, 2-chloro-, 3EVV74IJN6, NSC 8747, NSC-8747, EINECS 202-505-3, DTXSID8059132, DTXCID9048982, 202-505-3, MFCD00005421, chlorothiophene, 2-Chlorothiophene; 2-Thienyl chloride; NSC 8747, Thienyl chloride, 5-chlorothiophene, NSC8747, 2-chloro-thiophene, 2-Chlorothiophene, 96%, UNII-3EVV74IJN6, WLN: T5SJ BG, SCHEMBL29054, BIDD:GT0850, SCHEMBL183434, SCHEMBL183565, SCHEMBL350340, SCHEMBL1510074, SCHEMBL6396770, SCHEMBL7073829, STR06536, BBL027523, STL146684, AKOS000120017, AC-4913, PS-9231, DB-057632, C0807, NS00040479, ST50658272, EN300-20059, 2-Chlorothiophene, technical, >=95.0% (GC), ethyl (1R,2S)-2-phenylcyclopropanecarboxylate, F10317, InChI=1/C4H3ClS/c5-4-2-1-3-6-4/h1-3, F0001-2296

Application

2-Chlorothiophene serves as a key precursor in the synthesis of thiophene-based pharmaceuticals, including antipsychotics and antiviral agents. It is widely used in material science to create conductive polymers for organic electronics, such as OLEDs and OFETs. Additionally, this compound finds applications in agrochemical research for developing novel pesticides and herbicides due to its reactive halogen moiety.

Safety and Hazards

GHS Hazard Statements

• H225 (10.2%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H226 (89.8%): Flammable liquid and vapor [Warning Flammable liquids]
• H301 (12.2%): Toxic if swallowed [Danger Acute toxicity, oral]
• H311 (12.2%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H315 (87.8%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (87.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H330 (10.2%): Fatal if inhaled [Danger Acute toxicity, inhalation]
• H335 (85.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P280, P284, P301+P316, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P316, P319, P320, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (10.2%)
• Flam. Liq. 3 (89.8%)
• Acute Tox. 3 (12.2%)
• Acute Tox. 3 (12.2%)
• Skin Irrit. 2 (87.8%)
• Eye Irrit. 2 (87.8%)
• Acute Tox. 2 (10.2%)
• STOT SE 3 (85.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.