Description

2-Chloropyrimidine (CAS No. 1722-12-9) is a high-purity heterocyclic organic compound with the molecular formula C₄H₃ClN₂. This versatile chlorinated pyrimidine derivative is widely used as a key intermediate in pharmaceutical synthesis, agrochemical production, and materials science research. The compound features a reactive chlorine atom at the 2-position of the pyrimidine ring, making it an excellent electrophile for nucleophilic substitution reactions. Our product is rigorously tested to ensure ≥98% purity (GC) and is supplied as a clear, colorless to pale yellow liquid with a characteristic aromatic odor. Proper storage under inert atmosphere at 2-8°C is recommended to maintain stability. Suitable for use in Suzuki couplings, amination reactions, and other metal-catalyzed transformations. Available in quantities from grams to bulk kilograms with customizable packaging options.

Properties

• CAS Number: 1722-12-9
• Complexity: 51.7
• IUPAC Name: 2-chloropyrimidine
• InChI: InChI=1S/C4H3ClN2/c5-4-6-2-1-3-7-4/h1-3H
• InChI Key: UNCQVRBWJWWJBF-UHFFFAOYSA-N
• Exact Mass: 113.9984758
• Molecular Formula: C4H3ClN2
• Molecular Weight: 114.53
• SMILES: C1=CN=C(N=C1)Cl
• Topological: 25.8
• Monoisotopic Mass: 113.9984758
• Physical Description: Light yellow hygroscopic solid;
• Vapor Pressure: 2.48 [mmHg]
• Synonyms: 2-Chloropyrimidine, 1722-12-9, PYRIMIDINE, 2-CHLORO-, EINECS 217-020-2, NSC 43544, DTXSID70169214, Pyrimidine, 2chloro, DTXCID7091705, 217-020-2, inchi=1/c4h3cln2/c5-4-6-2-1-3-7-4/h1-3, un2811, uncqvrbwjwwjbf-uhfffaoysa-n, 2-chloro-pyrimidine, chloropyrimidine, MFCD00006060, CHEMBL5433017, NSC-43544, 2-Chloro-1,3-pyrimidine; NSC 43544; Pyrimidin-2-yl Chloride;, Chloropyrimidines, 2chloropyrimidine, chloro-pyrimidine, 2-chloropyrimidin, 2-chloropyrirnidine, NSC43544, 2-chloro pyrimidine, 2-pyrimidinyl chloride, Buspirone Intermediates, 2-Chloro-4-deoxyuracil, 2-Chloropyrimidine, 95%, 94EZW2WL9E, SCHEMBL27503, SCHEMBL226937, SCHEMBL451259, BCP26378, STR00974, BDBM50622795, SBB054479, STK803251, AKOS000120420, AB00572, AC-2505, CS-W008600, BP-13180, DB-024385, C1050, NS00025648, EN300-20306, Z104477694

Application

2-Chloropyrimidine serves as a crucial building block in medicinal chemistry for the synthesis of antiviral and anticancer agents. It is extensively used in the production of pyrimidine-based pharmaceuticals, including kinase inhibitors and nucleoside analogs. The compound finds application in agrochemical research for developing novel pesticides and herbicides. Researchers also utilize it as a precursor for functionalized pyrimidines in materials science applications.

Safety and Hazards

GHS Hazard Statements

• H301 (85.7%): Toxic if swallowed [Danger Acute toxicity, oral]
• H315 (12.5%): Causes skin irritation [Warning Skin corrosion/irritation]
• H317 (16.1%): May cause an allergic skin reaction [Warning Sensitization, Skin]
• H319 (91.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (12.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P272, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (85.7%)
• Skin Irrit. 2 (12.5%)
• Skin Sens. 1 (16.1%)
• Eye Irrit. 2 (91.1%)
• STOT SE 3 (12.5%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.