Description

2-Chloropyridin-4-amine (CAS No. 14432-12-3) is a high-purity heterocyclic organic compound with the molecular formula C₅H₅ClN₂. This fine chemical is widely utilized in pharmaceutical synthesis, agrochemical research, and material science due to its reactive amino and chloro functional groups. The product is supplied as a crystalline solid with guaranteed purity levels suitable for advanced research applications. Each batch undergoes rigorous quality control, including HPLC and NMR analysis, to ensure consistency and reliability. Ideal for use as a building block in medicinal chemistry, this compound is packaged under inert conditions to maintain stability and shelf life. Store in a cool, dry place away from light and moisture.

Properties

• CAS Number: 14432-12-3
• Complexity: 76.8
• IUPAC Name: 2-chloropyridin-4-amine
• InChI: InChI=1S/C5H5ClN2/c6-5-3-4(7)1-2-8-5/h1-3H,(H2,7,8)
• InChI Key: BLBDTBCGPHPIJK-UHFFFAOYSA-N
• Exact Mass: 128.0141259
• Molecular Formula: C5H5ClN2
• Molecular Weight: 128.56
• SMILES: C1=CN=C(C=C1N)Cl
• Topological: 38.9
• Monoisotopic Mass: 128.0141259
• Synonyms: 4-Amino-2-chloropyridine, 14432-12-3, 2-Chloropyridin-4-amine, 4-Pyridinamine, 2-chloro-, BHC29VF8KH, EINECS 238-403-0, DTXSID20162674, (2-CHLOROPYRIDIN-4-YL)AMINE, DTXCID0085165, 238-403-0, 2-Chloro-4-aminopyridine, 2-Chloro-pyridin-4-ylamine, MFCD00060089, 2-Chloro-4-pyridinamine, 4-AMINO-6-CHLOROPYRIDINE, 2-chloro-4-pyridylamine, 2-chloro-4-amino pyridine, 4-amino-2-chloro pyridine, (2-Chloropyridin-4-yl)amine; 2-Chloro-4-aminopyridine; 2-Chloropyridin-4-amine; 2-Chloro-4-pyridinamine;, UNII-BHC29VF8KH, 2-Chloro-4-amino-pyridine, 2-Chloro-4-pyridinamine #, SCHEMBL40039, SCHEMBL73460, SCHEMBL26933995, SCHEMBL28918027, SCHEMBL29001797, 4-Amino-2-chloropyridine, 97%, CHEBI:177030, BCP22213, CS-D1410, BBL009974, SBB004235, STK801373, AKOS001407522, AC-1168, PB24583, PS-3290, SB10355, SY004830, DB-009072, DB-349073, A0895, NS00010840, ST50949407, EN300-25778, F2145-0707, Z217306542

Application

2-Chloropyridin-4-amine serves as a versatile intermediate in the synthesis of pharmaceuticals, particularly in the development of kinase inhibitors and antiviral agents. Its reactive sites enable facile functionalization for the creation of complex heterocyclic scaffolds. Researchers also employ this compound in agrochemical formulations to develop novel pesticides and herbicides. Additionally, it finds use in material science for the preparation of specialized ligands and coordination polymers.

Safety and Hazards

GHS Hazard Statements

• H302 (15.1%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (15.1%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (15.1%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (98.1%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (15.1%)
• Acute Tox. 4 (15.1%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (15.1%)
• STOT SE 3 (98.1%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.