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Atomfair 2-(Chloromethyl)-3,5-difluoropyridine C6H4ClF2N CAS 1222633-85-3

2-(Chloromethyl)-3,5-difluoropyridine (CAS No. 1222633-85-3) is a high-purity fluorinated pyridine derivative with the molecular formula C6H4ClF2N . This organofluorine compound features a reactive chloromethyl group at the 2-position and fluorine substituents at the 3- and 5-positions of the pyridine ring, making it a versatile building block for pharmaceutical, agrochemical, and materials science applications. The compound is supplied as a clear to pale-yellow liquid with ≥95% purity (GC), packaged under inert gas to ensure stability. Its unique structure enables selective functionalization for synthesizing complex heterocycles, ligands, and biologically active molecules. Suitable for nucleophilic substitution, cross-coupling reactions, and as a precursor for fluorinated…

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Description

2-(Chloromethyl)-3,5-difluoropyridine (CAS No. 1222633-85-3) is a high-purity fluorinated pyridine derivative with the molecular formula C6H4ClF2N. This organofluorine compound features a reactive chloromethyl group at the 2-position and fluorine substituents at the 3- and 5-positions of the pyridine ring, making it a versatile building block for pharmaceutical, agrochemical, and materials science applications. The compound is supplied as a clear to pale-yellow liquid with ≥95% purity (GC), packaged under inert gas to ensure stability. Its unique structure enables selective functionalization for synthesizing complex heterocycles, ligands, and biologically active molecules. Suitable for nucleophilic substitution, cross-coupling reactions, and as a precursor for fluorinated scaffolds. Store at 2-8°C in a tightly sealed container.

Properties

  • CAS Number: 1222633-85-3
  • Complexity: 112
  • IUPAC Name: 2-(chloromethyl)-3,5-difluoro-pyridine
  • InChI: InChI=1S/C6H4ClF2N/c7-2-6-5(9)1-4(8)3-10-6/h1,3H,2H2
  • InChI Key: PNRQVTCCNSHPBG-UHFFFAOYSA-N
  • Exact Mass: 163.0000331
  • Molecular Formula: C6H4ClF2N
  • Molecular Weight: 163.55
  • SMILES: C1=C(C=NC(=C1F)CCl)F
  • Topological: 12.9
  • Monoisotopic Mass: 163.0000331
  • Synonyms: 2-(CHLOROMETHYL)-3,5-DIFLUOROPYRIDINE, 1222633-85-3, Pyridine, 2-(chloromethyl)-3,5-difluoro-, MFCD11520701, SCHEMBL9951955, PNRQVTCCNSHPBG-UHFFFAOYSA-N, XYB63385, 2-Chloromethyl-3,5-difluoropyridine, 2-chloromethyl-3,5-difluoro-pyridine, AKOS006324736, WS-01150, DB-226665, CS-0054348, P11155, EN300-7408877, F1916-8255

Application

2-(Chloromethyl)-3,5-difluoropyridine serves as a key intermediate in the synthesis of fluorinated pharmaceuticals, particularly kinase inhibitors and CNS-targeting compounds. Its chloromethyl group facilitates facile derivatization for constructing pyridine-based ligands in catalytic systems. The electron-withdrawing fluorine atoms enhance reactivity in nucleophilic aromatic substitution (SNAr) reactions, making it valuable for agrochemical development. Researchers also utilize this compound to create fluorinated analogs of bioactive molecules for structure-activity relationship (SAR) studies.

Safety and Hazards

GHS Hazard Statements

  • H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
  • H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P260, P261, P264, P270, P271, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P319, P321, P330, P363, P403+P233, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 4 (100%)
  • Skin Corr. 1B (100%)
  • STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

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Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

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  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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