Description

2-Chloro-N-methoxy-N-methylacetamide (CAS No. 67442-07-3) is a high-purity organic compound with the molecular formula C₄H₈ClNO₂. This versatile reagent is widely used in organic synthesis, particularly as a key intermediate in the preparation of pharmaceuticals, agrochemicals, and specialty chemicals. Its unique structure, featuring a chloroacetamide backbone with methoxy and methyl substituents on the nitrogen, makes it a valuable building block for nucleophilic substitution reactions and cross-coupling methodologies. Our product is rigorously tested to ensure >98% purity (HPLC/GC) and is supplied in sealed, light-resistant containers under inert atmosphere to guarantee stability and longevity. Ideal for research and industrial applications requiring precise and reliable performance.

Properties

• CAS Number: 67442-07-3
• Complexity: 86.1
• IUPAC Name: 2-chloro-N-methoxy-N-methyl-acetamide
• InChI: InChI=1S/C4H8ClNO2/c1-6(8-2)4(7)3-5/h3H2,1-2H3
• InChI Key: SCOJKGRNQDKFRP-UHFFFAOYSA-N
• Exact Mass: 137.0243562
• Molecular Formula: C4H8ClNO2
• Molecular Weight: 137.56
• SMILES: CN(C(=O)CCl)OC
• Topological: 29.5
• Monoisotopic Mass: 137.0243562
• Synonyms: 2-Chloro-N-methoxy-N-methylacetamide, N-methoxy-N-methylchloroacetamide, N-Methyl-N-methoxy-2-chloroacetamide, 2-Chloro-N-methoxy-N-methyl acetamide, Acetamide, 2-chloro-N-methoxy-N-methyl-, 2V3FHW6LWF, DTXSID90370461, .ALPHA.-CHLORO-N-METHOXY-N-METHYLACETAMIDE, DTXCID70321496, ALPHA-CHLORO-N-METHOXY-N-METHYLACETAMIDE, 629-377-5, 67442-07-3, MFCD00134232, Methyl 2-Chloro-N-methylacetohydroxamate, Acetamide,2-chloro-N-methoxy-N-methyl-, 2-chloro-N-methoxy-N-methyl-acetamide, UNII-2V3FHW6LWF, EC 629-377-5, SCHEMBL98900, 674420-70-3, N-methyl-N-methoxy chloroacetamide, STR09629, a-Chloro-N-methoxy-N-methylacetamide, AKOS005207299, CS-W001106, FC29200, N-methyloxy-N-methyl-2-chloroacetamide, AC-28975, SY002384, chloroacetic acid N-methyl-N-methoxy-amide, DB-013469, 2-Chloro-N-methoxy-N-methylacetamide, 98%, C2272, NS00005318, 2-CHLORO N-METHOXY N METHYL ACETAMIDE, EN300-93211, F1903-0107

Application

2-Chloro-N-methoxy-N-methylacetamide serves as a critical intermediate in the synthesis of active pharmaceutical ingredients (APIs) and fine chemicals. It is employed in the preparation of Weinreb amides, facilitating controlled carbonyl additions in complex molecule construction. Researchers utilize this compound in peptide coupling reactions and as a precursor for heterocyclic compounds. Its reactivity with nucleophiles makes it valuable for introducing chloroacetamide motifs into target molecules.

Safety and Hazards

GHS Hazard Statements

• H302 (87.5%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (87.5%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (14.6%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (12.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (87.5%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (12.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (87.5%)
• Acute Tox. 4 (87.5%)
• Skin Irrit. 2 (14.6%)
• Eye Irrit. 2 (12.5%)
• Acute Tox. 4 (87.5%)
• STOT SE 3 (12.5%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.