Description

2-Chloro-6-(trifluoromethoxy)pyridine (CAS No. 1221171-70-5) is a high-purity halogenated pyridine derivative with the molecular formula C₆H₃ClF₃NO. This specialized organic compound features a chloro-substitution at the 2-position and a trifluoromethoxy group at the 6-position of the pyridine ring, offering unique reactivity for advanced synthetic applications. With a molecular weight of 197.54 g/mol, it is supplied as a clear to pale-yellow liquid (or low-melting solid) with ≥95% purity (GC). Ideal for pharmaceutical intermediates, agrochemical synthesis, and ligand design in catalysis. Store under inert atmosphere at 2-8°C to maintain stability. Available in research (1g, 5g) and bulk quantities (100g, 1kg) with optional custom packaging. SDS and analytical certificates (COA, NMR, HPLC/GC-MS) provided.

Properties

• CAS Number: 1221171-70-5
• Complexity: 152
• IUPAC Name: 2-chloro-6-(trifluoromethoxy)pyridine
• InChI: InChI=1S/C6H3ClF3NO/c7-4-2-1-3-5(11-4)12-6(8,9)10/h1-3H
• InChI Key: GZFNUCAMADABAO-UHFFFAOYSA-N
• Exact Mass: 196.9855259
• Molecular Formula: C6H3ClF3NO
• Molecular Weight: 197.54
• SMILES: C1=CC(=NC(=C1)Cl)OC(F)(F)F
• Topological: 22.1
• Monoisotopic Mass: 196.9855259
• Synonyms: 2-chloro-6-(trifluoromethoxy)pyridine, 1221171-70-5, DTXSID70678831, DTXCID70629580, 822-427-9, Pyridine, 2-chloro-6-(trifluoromethoxy)-, MFCD18909427, SCHEMBL491468, SCHEMBL2302960, SCHEMBL23411488, GZFNUCAMADABAO-UHFFFAOYSA-N, BBL102579, STL556382, AKOS007929953, BK-0715, CS-W006368, SB12811, DA-28930, SY028167, EN300-106306

Application

2-Chloro-6-(trifluoromethoxy)pyridine serves as a key building block in the synthesis of trifluoromethoxy-containing bioactive molecules, particularly in crop protection agents and CNS-targeting pharmaceuticals. Its electron-deficient pyridine core enables efficient nucleophilic aromatic substitutions in medicinal chemistry. The compound is also utilized in metal-organic frameworks (MOFs) as a functionalized linker for gas storage applications. Researchers employ it to develop novel PET radiotracers due to the metabolic stability imparted by the trifluoromethoxy group.

Safety and Hazards

GHS Hazard Statements

• H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.