Description

2-Chloro-6-methylpyridine-3-carbonitrile (CAS No. 28900-10-9) is a high-purity organic compound with the molecular formula C₇H₅ClN₂. This versatile pyridine derivative is widely used in pharmaceutical and agrochemical research due to its reactive nitrile and chloro functional groups. Our product is synthesized under strict quality control measures, ensuring >98% purity by HPLC analysis. It is supplied as a white to off-white crystalline powder with excellent batch-to-batch consistency. Ideal for cross-coupling reactions, heterocyclic synthesis, and as a building block for more complex molecules. Available in quantities from grams to kilograms with customizable packaging options.

Key specifications:

• Molecular Weight: 152.58 g/mol
• Melting Point: 85-89°C
• Storage: Store at 2-8°C in a tightly sealed container
• Hazard Codes: Xi (Irritant)

Properties

• CAS Number: 28900-10-9
• Complexity: 160
• IUPAC Name: 2-chloro-6-methyl-pyridine-3-carbonitrile
• InChI: InChI=1S/C7H5ClN2/c1-5-2-3-6(4-9)7(8)10-5/h2-3H,1H3
• InChI Key: YSBNBAYNISAUIT-UHFFFAOYSA-N
• Exact Mass: 152.0141259
• Molecular Formula: C7H5ClN2
• Molecular Weight: 152.58
• SMILES: CC1=NC(=C(C=C1)C#N)Cl
• Topological: 36.7
• Monoisotopic Mass: 152.0141259
• Synonyms: 2-chloro-6-methylpyridine-3-carbonitrile, 628-229-7, 28900-10-9, 2-Chloro-6-methylnicotinonitrile, 2-Chloro-6-methyl-3-pyridinecarbonitrile, 2-Chloro-3-cyano-6-methylpyridine, MFCD00082767, 2-Chloro-6-methyl-nicotinonitrile, 3-Pyridinecarbonitrile, 2-chloro-6-methyl-, F3250-0678, 2-Chloro-3-cyano-6-picoline, 2-Chloro-6-methylnicotinonitrile; 2-Chloro-3-cyano-6-methylpyridine;, SCHEMBL333768, DTXSID60334338, SMSSF-0055529, 2-Chloro-6-methylnicotinonitrile #, ALBB-026313, CS-M1411, 2-Chloro-3-cyano-6-methyl pyridine, 2-chloro-3-cyano-6-methyl-pyridine, BBL028169, SBB006618, STL257893, TD8102, AKOS000274382, PB12067, 2-CHLORO-3-CYANO-6-METHYPYRIDINE, AC-24537, AS-17587, BP-12075, SY009246, DB-009941, 2-CHLORO-6-METHYL-3-PYRIDYL CYANIDE, ST45029695, EN300-43373, VU0607312-1, 2-Chloro-6-methyl-3-pyridinecarbonitrile, 98%, Z431973722

Application

2-Chloro-6-methylpyridine-3-carbonitrile serves as a key intermediate in the synthesis of various pharmaceutical compounds, particularly in the development of novel pyridine-based drug candidates. Researchers utilize this compound in palladium-catalyzed cross-coupling reactions to create more complex heterocyclic structures. The nitrile group offers versatile transformation possibilities, making it valuable for medicinal chemistry applications. It’s also employed in agrochemical research for developing new crop protection agents.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (91.3%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (10.9%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (89.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (89.1%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (91.3%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (10.9%)
• Eye Irrit. 2 (89.1%)
• Acute Tox. 4 (89.1%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.