Description

Description

2-Chloro-6-methoxypyridine (CAS No. 17228-64-7) is a high-purity heterocyclic organic compound with the molecular formula C₆H₆ClNO. This versatile chemical building block features a chloro-substituted pyridine ring with a methoxy group at the 6-position, offering unique reactivity for nucleophilic aromatic substitution and metal-catalyzed coupling reactions. Our product is rigorously tested to meet the highest standards (>98% purity by HPLC), ensuring consistency for pharmaceutical intermediates, agrochemical synthesis, and ligand preparation. Supplied as a clear to pale yellow liquid or low-melting solid with a characteristic pyridine odor. Packaged under inert gas in amber glass bottles to ensure stability. Technical data includes:

• Molecular Weight: 143.57 g/mol
• Boiling Point: ~220??C
• Density: 1.21 g/cm³
• Refractive Index: n_D²⁰ 1.530-1.534

Suitable for use under anhydrous conditions. Store at 2-8??C with desiccant.

Application

2-Chloro-6-methoxypyridine serves as a key intermediate in Suzuki-Miyaura and Buchwald-Hartwig coupling reactions for pharmaceutical API synthesis. The compound’s orthogonal reactivity enables selective functionalization at either the 2-chloro or 6-methoxy positions. Researchers utilize it in the development of kinase inhibitors, antimicrobial agents, and liquid crystal materials. Its electron-deficient pyridine core makes it valuable for constructing bidentate ligands in transition metal catalysis.

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