Description

2-Chloro-6-fluorotoluene (CAS No. 443-83-4) is a high-purity halogenated aromatic compound with the molecular formula C₇H₆ClF. This specialized chemical is widely utilized in organic synthesis, pharmaceutical intermediates, and agrochemical research due to its unique reactivity profile. The compound features a toluene backbone substituted with chlorine and fluorine at the 2- and 6-positions, respectively, making it a versatile building block for cross-coupling reactions, nucleophilic substitutions, and other advanced synthetic transformations.

Our product is rigorously tested to ensure ≥97% purity (GC), with stringent quality control for trace solvents and impurities. It is supplied as a clear, colorless to pale yellow liquid with a characteristic aromatic odor, packaged under inert gas to maintain stability. Ideal for researchers and industrial scientists, this reagent is compatible with air-sensitive protocols and is available in scalable quantities with customizable packaging options.

Key Specifications:

• CAS: 443-83-4
• Molecular Weight: 144.57 g/mol
• Boiling Point: ~175-177°C
• Density: ~1.19 g/cm³
• Refractive Index: n_D²⁰ ~1.495
• Storage: 2-8°C in airtight containers

Properties

• CAS Number: 443-83-4
• Complexity: 94.9
• IUPAC Name: 1-chloro-3-fluoro-2-methyl-benzene
• InChI: InChI=1S/C7H6ClF/c1-5-6(8)3-2-4-7(5)9/h2-4H,1H3
• InChI Key: FNPVYRJTBXHIPB-UHFFFAOYSA-N
• Exact Mass: 144.0142060
• Molecular Formula: C7H6ClF
• Molecular Weight: 144.57
• SMILES: CC1=C(C=CC=C1Cl)F
• Monoisotopic Mass: 144.0142060
• Synonyms: 2-Chloro-6-fluorotoluene, 443-83-4, 1-Chloro-3-fluoro-2-methylbenzene, Benzene, 1-chloro-3-fluoro-2-methyl-, EINECS 207-141-9, DTXSID1059997, EC 207-141-9, DTXCID8040301, 207-141-9, 2-FLUORO-6-CHLOROTOLUENE, 6-chloro-2-fluorotoluene, MFCD00000570, 1-chloro-3-fluoro-2-methyl-benzene, 2Cloro 6Fluorotoluene, 2-chloro-6-fluoro toluene, SCHEMBL108893, SCHEMBL535470, FR97UNN987, SCHEMBL2288283, SCHEMBL2345905, SCHEMBL2347090, SCHEMBL9494020, SCHEMBL9494026, FNPVYRJTBXHIPB-UHFFFAOYSA-, 2-Chloro-6-fluorotoluene, 97%, SBB086378, AKOS005063620, AC-7437, CS-W011001, C1181, NS00009147, EN300-85918, InChI=1/C7H6ClF/c1-5-6(8)3-2-4-7(5)9/h2-4H,1H3

2-Chloro-6-fluorotoluene serves as a critical intermediate in the synthesis of active pharmaceutical ingredients (APIs) and specialty chemicals. It is employed in Suzuki-Miyaura coupling reactions to construct biaryl scaffolds common in drug discovery. The compound’s halogen substituents enable regioselective functionalization for agrochemical development, particularly in herbicides and fungicides. Researchers also utilize it in material science for designing liquid crystals and optoelectronic materials.

Safety and Hazards

GHS Hazard Statements

• H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]
• H302 (84.8%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (84.8%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (13%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (13%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (84.8%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (10.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (100%)
• Acute Tox. 4 (84.8%)
• Acute Tox. 4 (84.8%)
• Skin Irrit. 2 (13%)
• Eye Irrit. 2 (13%)
• Acute Tox. 4 (84.8%)
• STOT SE 3 (10.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.