Description

2-Chloro-6-fluoroquinazolin-4-amine (CAS No. 192323-44-7) is a high-purity quinazoline derivative with the molecular formula C₈H₅ClFN₃. This compound is a valuable building block in medicinal chemistry and pharmaceutical research, particularly in the synthesis of kinase inhibitors and other bioactive molecules. Its unique structure, featuring both chloro and fluoro substituents, enhances its reactivity and selectivity in heterocyclic transformations. Ideal for researchers developing novel therapeutics, this product is rigorously tested for quality and consistency, ensuring reliable performance in synthetic applications. Available in various quantities to suit lab-scale and industrial needs.

Properties

• CAS Number: 192323-44-7
• Complexity: 192
• IUPAC Name: 2-chloro-6-fluoro-quinazolin-4-amine
• InChI: InChI=1S/C8H5ClFN3/c9-8-12-6-2-1-4(10)3-5(6)7(11)13-8/h1-3H,(H2,11,12,13)
• InChI Key: IOIRCNIDSMQRAL-UHFFFAOYSA-N
• Exact Mass: 197.0156030
• Molecular Formula: C8H5ClFN3
• Molecular Weight: 197.60
• SMILES: C1=CC2=C(C=C1F)C(=NC(=N2)Cl)N
• Topological: 51.8
• Monoisotopic Mass: 197.0156030
• Synonyms: 2-chloro-6-fluoroquinazolin-4-amine, 192323-44-7, DTXSID70653123, DTXCID00603873, 4-Amino-2-chloro-6-fluoroquinazoline, MFCD10697892, 2-chloro-6- fluoroquinazolin-4-amine, SCHEMBL8900878, AS458, AC5071, 4-Quinazolinamine,2-chloro-6-fluoro-, AKOS006303180, AB60758, AC-26855, SY007047, DB-065774, CS-0328418

Application

2-Chloro-6-fluoroquinazolin-4-amine serves as a key intermediate in the synthesis of quinazoline-based kinase inhibitors, which are critical in cancer research and targeted therapy development. Its reactive chloro and fluoro groups enable efficient functionalization for structure-activity relationship (SAR) studies. Researchers also utilize this compound in the design of antimicrobial and antiviral agents due to its heterocyclic scaffold. Its stability and versatility make it suitable for high-throughput screening and combinatorial chemistry applications.

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