Description

2-Chloro-6-fluoropyridine (CAS No. 20885-12-5) is a high-purity halogenated pyridine derivative with the molecular formula C₅H₃ClFN. This heterocyclic compound is widely utilized as a key intermediate in pharmaceutical synthesis, agrochemical production, and advanced material research. Its unique structure, featuring both chloro and fluoro substituents on the pyridine ring, makes it particularly valuable for nucleophilic substitution reactions and metal-catalyzed cross-coupling reactions.

Our product is rigorously tested to ensure ≥98% purity (GC) and is supplied in sealed containers under inert atmosphere to maintain stability. Available in quantities from grams to multi-kilogram scale, it is ideal for medicinal chemistry, ligand design, and as a building block for functionalized pyridine derivatives. The compound’s physicochemical properties (MW: 131.53 g/mol, density: 1.32 g/cm³) make it suitable for both solution-phase and solid-phase synthetic applications.

Special handling precautions are recommended due to potential toxicity – always use appropriate PPE and work in a fume hood. Technical data sheets with detailed spectral data (NMR, MS, IR) and chromatograms are available upon request.

Properties

• CAS Number: 20885-12-5
• Complexity: 78.8
• IUPAC Name: 2-chloro-6-fluoro-pyridine
• InChI: InChI=1S/C5H3ClFN/c6-4-2-1-3-5(7)8-4/h1-3H
• InChI Key: LXOHKRGLGLETIJ-UHFFFAOYSA-N
• Exact Mass: 130.9938050
• Molecular Formula: C5H3ClFN
• Molecular Weight: 131.53
• SMILES: C1=CC(=NC(=C1)Cl)F
• Topological: 12.9
• Monoisotopic Mass: 130.9938050
• Synonyms: 2-chloro-6-fluoropyridine, 20885-12-5, pyridine, 2-chloro-6-fluoro-, DTXSID70348648, DTXCID50299720, 675-592-2, inchi=1/c5h3clfn/c6-4-2-1-3-5(7)8-4/h1-3, 2-Chloro-6-fluoro-pyridine, 6-chloro-2-fluoropyridine, MFCD00077483, 2-FLUORO-6-CHLOROPYRIDINE, Pyridine,2-chloro-6-fluoro-, SCHEMBL115958, SCHEMBL481763, SCHEMBL1043006, SCHEMBL1044558, LXOHKRGLGLETIJ-UHFFFAOYSA-N, BCP22169, SBB085792, AKOS005063944, AB02970, CS-W005021, PS-9137, AC-24488, SY017696, DB-025878, C3186, EN300-98252

Application

2-Chloro-6-fluoropyridine serves as a versatile precursor in the synthesis of biologically active molecules, particularly in developing novel kinase inhibitors and antimicrobial agents. In material science, it functions as a ligand precursor for transition metal complexes used in catalysis. The compound’s dual halogen functionality enables selective functionalization at either the 2- or 6-position, making it valuable for structure-activity relationship studies in drug discovery programs.

Safety and Hazards

GHS Hazard Statements

• H302+H312+H332 (40%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
• H302 (40%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (20%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (40%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (60%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (20%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (80%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (40%)
• Acute Tox. 4 (20%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (40%)
• Eye Irrit. 2 (60%)
• Acute Tox. 4 (20%)
• STOT SE 3 (80%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.