Description

2-Chloro-6-fluoroanisole (CAS No. 53145-38-3) is a high-purity aromatic ether compound with the molecular formula C₇H₆ClFO and IUPAC name 1-chloro-3-fluoro-2-methoxybenzene. This specialized chemical is widely utilized in pharmaceutical synthesis, agrochemical development, and advanced material research. As a halogenated anisole derivative, it serves as a versatile building block for introducing methoxy, chloro, and fluoro substituents into complex molecular architectures. Our product is rigorously quality-controlled to ensure exceptional purity (>98%) and consistency, making it ideal for demanding applications in medicinal chemistry and fine chemical synthesis. Supplied in amber glass bottles under inert atmosphere to ensure stability, this compound is a critical intermediate for researchers developing novel bioactive compounds and functional materials.

Properties

• CAS Number: 53145-38-3
• Complexity: 110
• IUPAC Name: 1-chloro-3-fluoro-2-methoxy-benzene
• InChI: InChI=1S/C7H6ClFO/c1-10-7-5(8)3-2-4-6(7)9/h2-4H,1H3
• InChI Key: QASFEHCRPLPGES-UHFFFAOYSA-N
• Exact Mass: 160.0091207
• Molecular Formula: C7H6ClFO
• Molecular Weight: 160.57
• SMILES: COC1=C(C=CC=C1Cl)F
• Topological: 9.2
• Monoisotopic Mass: 160.0091207
• Synonyms: 2-Chloro-6-fluoroanisole, 53145-38-3, DTXSID20378571, DTXCID70329598, 640-287-5, 1-chloro-3-fluoro-2-methoxybenzene, 1-chloro-3-fluoro-2-methoxy-benzene, MFCD01631573, 2-Chloro-6-fluoro anisole, SCHEMBL719277, SCHEMBL1703057, SCHEMBL2285403, SCHEMBL2345893, SCHEMBL3759260, SBB087474, AKOS006227787, 2-Chloro-6-fluorophenol, methyl ether, CS-W013269, PS-8769, DA-18180, DB-192773, ST50407432, 1-Chloro-3-fluoro-2-methoxybenzene, AldrichCPR, EN300-7304882

Application

2-Chloro-6-fluoroanisole is primarily employed as a key synthetic intermediate in pharmaceutical research, particularly in the development of active pharmaceutical ingredients (APIs) with halogenated aromatic moieties. The compound’s unique substitution pattern makes it valuable for constructing complex molecules in medicinal chemistry programs targeting CNS disorders and antimicrobial agents. Additionally, it finds use in material science for creating specialized polymers and liquid crystals where controlled halogen substitution is required. The simultaneous presence of ortho-chloro and meta-fluoro substituents adjacent to the methoxy group enables selective functionalization in cross-coupling reactions.

Safety and Hazards

GHS Hazard Statements

• H317 (87.3%): May cause an allergic skin reaction [Warning Sensitization, Skin]

Precautionary Statements

• P261, P272, P280, P302+P352, P321, P333+P317, P362+P364, and P501

Hazard Classes and Categories

• Skin Sens. 1 (87.3%)

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