Description

2-Chloro-5-nitropyridine (CAS No. 4548-45-2) is a high-purity heterocyclic organic compound with the molecular formula C₅H₃ClN₂O₂. This pale yellow to off-white crystalline solid is a versatile intermediate in pharmaceutical, agrochemical, and specialty chemical synthesis. With a molecular weight of 158.54 g/mol, it features a reactive chloro group at the 2-position and an electron-withdrawing nitro group at the 5-position, making it ideal for nucleophilic substitution and cross-coupling reactions. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied in sealed containers under inert atmosphere to prevent degradation. Suitable for use in Suzuki, Stille, and Buchwald-Hartwig reactions.

Properties

• CAS Number: 4548-45-2
• Complexity: 136
• IUPAC Name: 2-chloro-5-nitro-pyridine
• InChI: InChI=1S/C5H3ClN2O2/c6-5-2-1-4(3-7-5)8(9)10/h1-3H
• InChI Key: BAZVFQBTJPBRTJ-UHFFFAOYSA-N
• Exact Mass: 157.9883050
• Molecular Formula: C5H3ClN2O2
• Molecular Weight: 158.54
• SMILES: C1=CC(=NC=C1[N+](=O)[O-])Cl
• Topological: 58.7
• Monoisotopic Mass: 157.9883050
• Synonyms: 2-Chloro-5-nitropyridine, 4548-45-2, Pyridine, 2-chloro-5-nitro-, EINECS 224-908-3, NSC 4468, BRN 0120453, AI3-19230, DTXSID70196525, 5-20-05-00452 (Beilstein Handbook Reference), DTXCID10119016, 224-908-3, 4585-45-2, bazvfqbtjpbrtj-uhfffaoysa-n, inchi=1/c5h3cln2o2/c6-5-2-1-4(3-7-5)8(9)10/h1-3, 2-chloro-5-nitro-pyridine, 3-Nitro-6-chloropyridine, 2-chloro-5-nitro pyridine, MFCD00006240, 34515-81-6, NSC-4468, 5-nitro-2-chloropyridine, NSC4468, chloro-5-nitropyridine, 2chloro-5-nitropyridine, 2-chloro-5-nitropyridin, 2-cloro-5-nitropyridine, 6-chloro-3-nitropyridine, 2-chloro-5-riitropyridine, 2-chloro -5-nitropyridine, 2-chloro–5-nitropyridine, 5-nitro-2-chloro pyridine, 5-nitro-2-chloro-pyridine, WLN: T6NJ BG ENW, SCHEMBL5473, 2-chloro-5-(nitro)pyridine, SCHEMBL1531229, SCHEMBL14145676, SCHEMBL28717323, 2-Chloro-5-nitropyridine, 99%, 6L92DZ2L45, BCP26970, STR00179, BBL009800, RB1109, SBB054353, STK801263, AKOS000120380, AB00655, AC-2462, CS-W013280, FC00121, FG-0498, HY-W012564, NCGC00334089-01, BP-11373, DB-005226, A7161, NS00031538, ST50208947, EN300-18310, AB00443457-03, AC-907/30002041, 2-Chloro-5-nitropyridine, purum, >=97.0% (AT), Q63391986, Z57834470, F3284-7504

Application

2-Chloro-5-nitropyridine serves as a key building block in the synthesis of pharmaceutical compounds, particularly for antiviral and antibacterial agents. It is widely employed in agrochemical production for creating novel pesticides and herbicides. Researchers utilize this compound as a precursor in the development of liquid crystals and other advanced materials.

Safety and Hazards

GHS Hazard Statements

• H302 (14%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (98%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (14%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (98%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.