Description

2-Chloro-5-methyl-pyridine (CAS No. 18368-64-4) is a high-purity heterocyclic organic compound with the molecular formula C₆H₆ClN. This versatile chemical intermediate features a chlorinated pyridine ring substituted with a methyl group at the 5-position, offering excellent reactivity for further functionalization. Available in >98% purity (GC), it is supplied as a clear to pale-yellow liquid with a characteristic pyridine-like odor. Ideal for pharmaceutical synthesis, agrochemical production, and material science research, this compound is rigorously tested for consistency and quality. Proper storage under inert atmosphere at 2-8°C is recommended to maintain stability. Suitable for nucleophilic substitution reactions, metal-catalyzed cross-couplings, and as a building block for more complex nitrogen-containing architectures. Packaged in amber glass bottles or sealed metal drums with optional argon padding for oxygen-sensitive applications.

Properties

• CAS Number: 18368-64-4
• Complexity: 74.9
• IUPAC Name: 2-chloro-5-methyl-pyridine
• InChI: InChI=1S/C6H6ClN/c1-5-2-3-6(7)8-4-5/h2-4H,1H3
• InChI Key: VXLYOURCUVQYLN-UHFFFAOYSA-N
• Exact Mass: 127.0188769
• Molecular Formula: C6H6ClN
• Molecular Weight: 127.57
• SMILES: CC1=CN=C(C=C1)Cl
• Topological: 12.9
• Monoisotopic Mass: 127.0188769
• Synonyms: 2-Chloro-5-methylpyridine, 6-Chloro-3-picoline, 2-chloro-5-methyl-pyridine, DTXSID00342396, EC 418-050-0, DTXCID60293476, 418-050-0, 629-246-2, 18368-64-4, 2-Chloro-5-picoline, Pyridine, 2-chloro-5-methyl-, MFCD00792460, 2-chloro-5-methyl pyridine, 3-Picoline, 6-chloro-, 5-methyl-2-chloropyridine, 6-chloro-3-methylpyridine, 2-Chloro-5-methyl-pyridin, 2-Chloro-5-methylpyridine (2-Chloro-5-picoline), SCHEMBL82409, SCHEMBL359177, SCHEMBL790783, 2-chloranyl-5-methyl-pyridine, SCHEMBL3061627, SCHEMBL28725750, 2-Chloro-5-methylpyridine, 97%, BCP19250, BBL102443, SBB085698, STL556245, AKOS000121119, AB07104, CS-W013478, AC-10768, SY007972, TS-01674, DB-015946, C1999, NS00006708, ST51038488, EN300-27031, A812809, F0001-0666, InChI=1/C6H6ClN/c1-5-2-3-6(7)8-4-5/h2-4H,1H

Application

2-Chloro-5-methylpyridine serves as a key intermediate in the synthesis of neonicotinoid insecticides and other crop protection agents. Pharmaceutical researchers utilize this compound in developing receptor antagonists and kinase inhibitors due to its privileged pyridine scaffold. The chlorine and methyl substituents provide orthogonal reactivity for sequential functionalization in medicinal chemistry applications. It’s also employed in ligand design for transition metal catalysts and as a precursor for specialty polymers with tailored electronic properties.

Safety and Hazards

GHS Hazard Statements

• H302: Harmful if swallowed [Warning Acute toxicity, oral]
• H312: Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315: Causes skin irritation [Warning Skin corrosion/irritation]
• H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P264, P270, P273, P280, P301+P317, P302+P352, P317, P321, P330, P332+P317, P362+P364, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 3 (95.7%)
• Acute Tox. 4 (12.8%)
• Skin Irrit. 2 (100%)
• Aquatic Chronic 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.