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Atomfair 2-Chloro-5-iodo-3-nitropyridine C5H2ClIN2O2 CAS 426463-05-0

2-Chloro-5-iodo-3-nitropyridine (CAS No. 426463-05-0) is a high-purity halogenated nitropyridine compound with the molecular formula C5H2ClIN2O2. This heterocyclic aromatic compound is characterized by its chloro, iodo, and nitro functional groups, making it a versatile intermediate for organic synthesis and pharmaceutical research. With a molecular weight of 284.44 g/mol, it is supplied as a crystalline solid with >95% purity (HPLC). Ideal for cross-coupling reactions, nucleophilic substitutions, and as a precursor for agrochemicals or drug discovery. Store in a cool, dry place under inert conditions to ensure stability.

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Description

2-Chloro-5-iodo-3-nitropyridine (CAS No. 426463-05-0) is a high-purity halogenated nitropyridine compound with the molecular formula C5H2ClIN2O2. This heterocyclic aromatic compound is characterized by its chloro, iodo, and nitro functional groups, making it a versatile intermediate for organic synthesis and pharmaceutical research. With a molecular weight of 284.44 g/mol, it is supplied as a crystalline solid with >95% purity (HPLC). Ideal for cross-coupling reactions, nucleophilic substitutions, and as a precursor for agrochemicals or drug discovery. Store in a cool, dry place under inert conditions to ensure stability.

Properties

  • CAS Number: 426463-05-0
  • Complexity: 163
  • IUPAC Name: 2-chloro-5-iodo-3-nitro-pyridine
  • InChI: InChI=1S/C5H2ClIN2O2/c6-5-4(9(10)11)1-3(7)2-8-5/h1-2H
  • InChI Key: PIJMRJPJERUFNI-UHFFFAOYSA-N
  • Exact Mass: 283.88495
  • Molecular Formula: C5H2ClIN2O2
  • Molecular Weight: 284.44
  • SMILES: C1=C(C=NC(=C1[N+](=O)[O-])Cl)I
  • Topological: 58.7
  • Monoisotopic Mass: 283.88495
  • Synonyms: 2-Chloro-5-iodo-3-nitropyridine, 426463-05-0, DTXSID50363839, DTXCID50314886, 686-984-8, 2-chloro-5-iodo-3-nitro-pyridine, MFCD04038568, SCHEMBL1600705, 5-iodo-3-nitro-2-chloropyridine, PIJMRJPJERUFNI-UHFFFAOYSA-N, GEO-03609, AKOS016007130, CS-W020533, DS-2552, PB26113, 2-Chloro-5-iodo-3-nitropyridine, 97%, 2-Chloro-5-iodo-3-nitropyridine, 98%, AC-27506, SY096986, DB-081219, C30180, EN300-103316

Application

2-Chloro-5-iodo-3-nitropyridine serves as a key building block in medicinal chemistry for the synthesis of bioactive molecules, particularly kinase inhibitors and antimicrobial agents. Its reactive halogen and nitro groups facilitate Suzuki-Miyaura and Buchwald-Hartwig couplings in pharmaceutical R&D. The compound is also employed in material science for designing nitrogen-rich heterocyclic frameworks.

Safety and Hazards

GHS Hazard Statements

  • H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
  • H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 4 (100%)
  • Skin Irrit. 2 (100%)
  • Eye Dam. 1 (100%)
  • STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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