Description

2-Chloro-5-hydroxypyridine (CAS No. 41288-96-4) is a high-purity heterocyclic compound with the molecular formula C₅H₄ClNO. This versatile intermediate is widely used in pharmaceutical synthesis, agrochemical development, and material science research. Its unique pyridine core with chloro and hydroxyl substitutions makes it a valuable building block for nucleophilic aromatic substitution reactions and metal-catalyzed cross-coupling processes. Our product is supplied as a white to off-white crystalline powder with guaranteed >98% purity by HPLC analysis, packaged under inert atmosphere to ensure stability. Suitable for use as a precursor in API manufacturing, ligand synthesis, and as a scaffold for drug discovery programs targeting neurological and infectious diseases.

Properties

• CAS Number: 41288-96-4
• Complexity: 78.8
• IUPAC Name: 6-chloropyridin-3-ol
• InChI: InChI=1S/C5H4ClNO/c6-5-2-1-4(8)3-7-5/h1-3,8H
• InChI Key: KVCOOWROABTXDJ-UHFFFAOYSA-N
• Exact Mass: 128.9981414
• Molecular Formula: C5H4ClNO
• Molecular Weight: 129.54
• SMILES: C1=CC(=NC=C1O)Cl
• Topological: 33.1
• Monoisotopic Mass: 128.9981414
• Synonyms: 2-Chloro-5-hydroxypyridine, 41288-96-4, DTXSID50356120, DTXCID70307179, 670-289-1, 6-chloropyridin-3-ol, 6-Chloro-3-pyridinol, MFCD00234050, 3-PYRIDINOL, 6-CHLORO-, 2-chloro-5-hydroxy pyridine, 2-chloro-5-pyridinol, 6-chloropyridine-3-ol, 6-chloro-pyridin-3-ol, 5-hydroxy-2-chloropyridine, 2-chloro-5-hydroxy-pyridine, SCHEMBL199726, SCHEMBL323724, CHEMBL3236918, SCHEMBL22089651, BCP22997, CS-D0979, BBL100861, SBB054276, STL554655, AKOS005255525, AC-2884, FC00525, PB32188, PS-6142, 2-Chloro-5-hydroxypyridine, AldrichCPR, BP-10824, SY003236, DB-006069, A6846, C2271, 2-Chloro-5-pyridinol; 6-Chloropyridin-3-ol, EN300-52976, AM-977/25004381

2-Chloro-5-hydroxypyridine serves as a key intermediate in the synthesis of neonicotinoid insecticides and pharmaceutical compounds. Researchers utilize this compound for developing novel kinase inhibitors and CNS-active agents due to its privileged pyridine scaffold. The reactive chloro and hydroxyl groups allow for sequential functionalization in multi-step synthetic routes. In material science, it finds application as a precursor for conductive polymers and metal-organic frameworks (MOFs). The compound’s stability under various reaction conditions makes it particularly valuable for parallel synthesis and combinatorial chemistry approaches.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (90.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (90.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.