Description

2-Chloro-5-Fluorobenzaldehyde (CAS No. 84194-30-9) is a high-purity aromatic aldehyde featuring both chloro and fluoro substituents, making it a versatile building block in organic synthesis. With the molecular formula C₇H₄ClFO, this compound is characterized by its reactive aldehyde group, which facilitates condensation, nucleophilic addition, and other key transformations. Ideal for pharmaceutical, agrochemical, and materials science research, it is supplied as a crystalline solid with guaranteed purity (typically ≥98%) and rigorous QC validation via GC/HPLC and NMR. Suitable for use in Suzuki couplings, Grignard reactions, and heterocycle synthesis, this reagent is packaged under inert conditions to ensure stability and longevity. Store in a cool, dry place away from light and oxidizing agents.

Properties

• CAS Number: 84194-30-9
• Complexity: 129
• IUPAC Name: 2-chloro-5-fluoro-benzaldehyde
• InChI: InChI=1S/C7H4ClFO/c8-7-2-1-6(9)3-5(7)4-10/h1-4H
• InChI Key: SOEFVBXUNROUOX-UHFFFAOYSA-N
• Exact Mass: 157.9934706
• Molecular Formula: C7H4ClFO
• Molecular Weight: 158.56
• SMILES: C1=CC(=C(C=C1F)C=O)Cl
• Topological: 17.1
• Monoisotopic Mass: 157.9934706
• Synonyms: 2-Chloro-5-Fluorobenzaldehyde, 84194-30-9, DTXSID20381308, DTXCID00332333, 678-371-9, MFCD03788511, Benzaldehyde, 2-chloro-5-fluoro-, 2-Chloro-5-Fluoro benzaldehyde, 5-FLUORO-2-CHLOROBENZALDEHYDE, 2-chloro-5-fluoro-benzaldehyde, SCHEMBL1853771, SCHEMBL6212276, SOEFVBXUNROUOX-UHFFFAOYSA-N, SBB063392, 2-Chloro-5-fluorobenZaldehyde, 95%, AKOS005258257, AC-2777, CS-W003102, PS-8802, SY002882, 2-Chloro-5-fluorobenzaldehyde, AldrichCPR, DB-005223, C2381, EN300-155181, Z1201622451

Application

2-Chloro-5-Fluorobenzaldehyde serves as a critical intermediate in the synthesis of bioactive molecules, including pharmaceuticals and agrochemicals. Its aldehyde group enables facile derivatization into Schiff bases or heterocyclic scaffolds like quinolines and benzimidazoles. Researchers also employ it in cross-coupling reactions to construct complex fluorinated aromatics for material science applications. The compound’s halogenated structure enhances electron-deficient character, useful in designing OLEDs or liquid crystals.

Safety and Hazards

GHS Hazard Statements

• H302 (60%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (20%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (80%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (80%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (60%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (20%)
• Eye Irrit. 2 (80%)
• STOT SE 3 (80%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.