Description

2-Chloro-5-fluoroaniline (CAS No. 452-83-5) is a high-purity halogenated aniline derivative with the molecular formula C₆H₅ClFN. This fine chemical is a valuable intermediate in organic synthesis, featuring both chloro and fluoro substituents on the aromatic ring, which enhance its reactivity and utility in cross-coupling reactions. Ideal for pharmaceutical, agrochemical, and materials science research, our product is rigorously tested to meet the highest standards of purity (typically ≥98% by GC) and consistency. Supplied in sealed amber vials or bulk packaging under inert gas to ensure stability, it is a critical building block for the development of fluorinated active ingredients and specialty chemicals. SDS and analytical certificates available upon request.

Properties

• CAS Number: 452-83-5
• Complexity: 99.1
• IUPAC Name: 2-chloro-5-fluoro-aniline
• InChI: InChI=1S/C6H5ClFN/c7-5-2-1-4(8)3-6(5)9/h1-3H,9H2
• InChI Key: VWUFOZAFKYOZJB-UHFFFAOYSA-N
• Exact Mass: 145.0094550
• Molecular Formula: C6H5ClFN
• Molecular Weight: 145.56
• SMILES: C1=CC(=C(C=C1F)N)Cl
• Topological: 26
• Monoisotopic Mass: 145.0094550
• Synonyms: 2-Chloro-5-fluoroaniline, 452-83-5, DTXSID90371413, DTXCID10322447, 610-238-2, 5-Fluoro-2-chloroaniline, MFCD00084852, 2-chloranyl-5-fluoranyl-aniline, 2-Chloro-5-fluorobenzeneamine, SCHEMBL75488, 2-chloro-5-fluorophenylamine, 2-chloro-5-fluoro-phenyl amine, SCHEMBL27578699, CK1177, SBB069992, STL164363, AKOS005363775, AC-3666, CCG-302536, CS-W010996, DS-12550, DB-020852, C1693, EN300-68230, A826759, A829414, F0001-2438, Z1089905956

Application

2-Chloro-5-fluoroaniline serves as a key precursor in the synthesis of fluorinated pharmaceuticals, particularly in the development of kinase inhibitors and antimicrobial agents. Its dual halogen functionality enables selective functionalization in Suzuki-Miyaura and Buchwald-Hartwig coupling reactions. Researchers also utilize it to construct heterocyclic scaffolds in agrochemicals, such as herbicides and fungicides. The compound’s electron-withdrawing properties make it valuable in materials science for designing liquid crystals and OLED intermediates.

Safety and Hazards

GHS Hazard Statements

• H301 (25%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302 (75%): Harmful if swallowed [Warning Acute toxicity, oral]
• H311 (87.5%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H312 (12.5%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (75%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (75%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H331 (12.5%): Toxic if inhaled [Danger Acute toxicity, inhalation]
• H332 (75%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H373 (62.5%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Precautionary Statements

• P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (25%)
• Acute Tox. 4 (75%)
• Acute Tox. 3 (87.5%)
• Acute Tox. 4 (12.5%)
• Skin Irrit. 2 (75%)
• Eye Irrit. 2 (75%)
• Acute Tox. 3 (12.5%)
• Acute Tox. 4 (75%)
• STOT RE 2 (62.5%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.