Description

2-Chloro-4,6-difluoroaniline (CAS No. 36556-56-6) is a high-purity aromatic amine derivative with the molecular formula C₆H₄ClF₂N. This compound is a valuable intermediate in organic synthesis, featuring a reactive aniline group flanked by chloro and fluoro substituents at the 2, 4, and 6 positions, respectively. Its unique electronic and steric properties make it ideal for pharmaceutical, agrochemical, and materials science applications. Available in >98% purity (GC), it is supplied as a crystalline solid with strict quality control to ensure consistency in research and industrial processes. Store under inert conditions to maintain stability.

Properties

• CAS Number: 36556-56-6
• Complexity: 122
• IUPAC Name: 2-chloro-4,6-difluoro-aniline
• InChI: InChI=1S/C6H4ClF2N/c7-4-1-3(8)2-5(9)6(4)10/h1-2H,10H2
• InChI Key: DUPRZIYJXCCXQZ-UHFFFAOYSA-N
• Exact Mass: 163.0000331
• Molecular Formula: C6H4ClF2N
• Molecular Weight: 163.55
• SMILES: C1=C(C=C(C(=C1F)N)Cl)F
• Topological: 26
• Monoisotopic Mass: 163.0000331
• Synonyms: 2-Chloro-4,6-difluoroaniline, 36556-56-6, DTXSID20370111, DTXCID60321147, 622-778-6, Benzenamine, 2-chloro-4,6-difluoro-, MFCD00142892, 6-Chloro-2,4-difluoroaniline, EN300-109333, 2-chloro-4,6-difluorophenylamine, 4,6-Difluoro-2-chloroaniline, SCHEMBL899027, 2-chloro-4,6 difluoro aniline, 2-Chloro-4,6-difluorobenzenamine, BDBM625977, SBB003922, TD1259, 2-Chloro-4,6-difluoroaniline, 97%, AKOS015890088, AC-3664, CS-W013250, FC70184, SB75746, CS-17359, SY022857, DB-020805, C1777, ST50406073

Application

2-Chloro-4,6-difluoroaniline serves as a versatile building block in the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates. It is also employed in agrochemical research for creating herbicidal and pesticidal compounds. The electron-withdrawing effects of the chloro and fluoro groups enhance its reactivity in nucleophilic aromatic substitution (S_NAr) reactions, making it useful for constructing complex heterocycles.

Safety and Hazards

GHS Hazard Statements

• H301 (89.1%): Toxic if swallowed [Danger Acute toxicity, oral]
• H311 (10.9%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H315 (97.8%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (87%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (10.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Precautionary Statements

• P262, P264, P264+P265, P270, P280, P301+P316, P302+P352, P305+P351+P338, P305+P354+P338, P316, P317, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (89.1%)
• Skin Irrit. 2 (97.8%)
• Eye Dam. 1 (87%)
• Eye Irrit. 2 (10.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.