Description

2-Chloro-4-methyl-6,7-dihydro-5H-cyclopenta[b]pyridin-7-ol (CAS: 745075-80-3) is a high-purity heterocyclic compound with the molecular formula C₉H₁₀ClNO. This fine chemical features a cyclopenta[b]pyridine core substituted with chloro and methyl groups at the 2- and 4-positions, respectively, along with a hydroxyl group at the 7-position. The compound is supplied as a white to off-white crystalline powder with ≥95% purity (HPLC), ideal for pharmaceutical research and organic synthesis. It is packaged under inert gas in amber glass vials to ensure stability and longevity. This building block is particularly valuable for medicinal chemistry applications, including the development of kinase inhibitors and other biologically active molecules. Researchers can utilize this compound for lead optimization, scaffold modification, or as a precursor for more complex structures.

Properties

• CAS Number: 745075-80-3
• Complexity: 176
• IUPAC Name: 2-chloro-4-methyl-6,7-dihydro-5H-cyclopenta[b]pyridin-7-ol
• InChI: InChI=1S/C9H10ClNO/c1-5-4-8(10)11-9-6(5)2-3-7(9)12/h4,7,12H,2-3H2,1H3
• InChI Key: HVRUTPMBYKOXBN-UHFFFAOYSA-N
• Exact Mass: 183.0450916
• Molecular Formula: C9H10ClNO
• Molecular Weight: 183.63
• SMILES: CC1=CC(=NC2=C1CCC2O)Cl
• Topological: 33.1
• Monoisotopic Mass: 183.0450916
• Synonyms: 2-Chloro-4-methyl-6,7-dihydro-5H-cyclopenta[b]pyridin-7-ol, 745075-80-3, 2-CHLORO-4-METHYL-5H,6H,7H-CYCLOPENTA[B]PYRIDIN-7-OL, 2-Chloro-4-methyl-6,7-dihydro-5H-cyclopenta[b]pyridine-7-ol, E86060

Application

This chlorinated cyclopenta[b]pyridine derivative serves as a versatile intermediate in medicinal chemistry, particularly for developing kinase inhibitors and other small molecule therapeutics. The compound’s unique scaffold makes it valuable for structure-activity relationship studies in drug discovery programs. Researchers utilize it as a building block for constructing more complex heterocyclic systems with potential biological activity. The hydroxyl group provides a handle for further functionalization through various synthetic transformations.

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